Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection
Background/Aim. Hepatitis C is an important sociomedical problem worldwide due to frequent progression to chronic disease, occurrence of liver cirrhosis and hepatocellular carcinoma. Standard pegylated interferon alfa 2a plus ribavirin therapy results in resolution of infection only in 50%...
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Military Health Department, Ministry of Defance, Serbia
2015-01-01
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doaj-28431278a1a3447ebb2f36d029f2e3362020-11-25T01:02:22ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502015-01-0172650550910.2298/VSP1506505V0042-84501506505VAssociation between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infectionVuković Vuk R.0Baskić Dejan1Mijailović Željko2Đurđević Predrag3Jovanović Danijela4Mitrović Slobodanka5Popović Suzana6Garrison Clinic, KragujevacFaculty of Medicinal Sciences, Center for Molecular Medicine and Stem Cell Research, Kragujevac + Public Health Institute of Kragujevac, KragujevacClinical Center of Kragujevac, Department of Infectious Diseases, KragujevacClinical Center of Kragujevac, Department of Hematology, KragujevacClinical Center of Kragujevac, Department of Hematology, KragujevacFaculty of Medicinal Sciences, Center for Pathological Anatomy, KragujevacFaculty of Medicinal Sciences, Center for Molecular Medicine and Stem Cell Research, KragujevacBackground/Aim. Hepatitis C is an important sociomedical problem worldwide due to frequent progression to chronic disease, occurrence of liver cirrhosis and hepatocellular carcinoma. Standard pegylated interferon alfa 2a plus ribavirin therapy results in resolution of infection only in 50% of patients. The aim of this study was to determine the association of various factors with response to the therapy in patients with chronic hepatitis C virus (HCV) infection. Age and sex of patients, inoculation risk factors, histopathological changes in the liver, viral load and HCV genotype were analyzed. Methods. The study included a group of 121 patients with chronic HCV infection. The treatment was carried out 24 weeks for virus genotype 2 and 3, and 48 weeks for genotype 1 and 4. The degree of histopathological changes in the liver was determined by hematoxylin and eosin staining, whereas polimerase chain reaction was used for HCV genotyping. Results. In the group of non-responding patients genotype 1 was represented with 100%, while in the other groups, although predominantly present, its percentage was lower. Unresponsiveness to therapy and relapse of disease were associated with higher viral load and advanced fibrosis. Intravenous use of psychoactive substances, as a risk factor, was present in a high percentage in the group of patients with sustained response, while blood transfusion and dialysis were leading risk factors in the group of relapse responders and non-responders. Conclusion. The results of our study showed that the treatment outcome of chronic HCV infection was associated with baseline HCV ribonucleic acid, HCV genotype, route of infection and the degree of histopathological changes in the liver. [Projekat Ministarstva nauke Republike Srbije, br. III41010]http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501506505V.pdfhepatitis Chepatitis, chronictreatment outcomerisk factorsgenotypehistological techniquesdisease transmission, infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vuković Vuk R. Baskić Dejan Mijailović Željko Đurđević Predrag Jovanović Danijela Mitrović Slobodanka Popović Suzana |
spellingShingle |
Vuković Vuk R. Baskić Dejan Mijailović Željko Đurđević Predrag Jovanović Danijela Mitrović Slobodanka Popović Suzana Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection Vojnosanitetski Pregled hepatitis C hepatitis, chronic treatment outcome risk factors genotype histological techniques disease transmission, infections |
author_facet |
Vuković Vuk R. Baskić Dejan Mijailović Željko Đurđević Predrag Jovanović Danijela Mitrović Slobodanka Popović Suzana |
author_sort |
Vuković Vuk R. |
title |
Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection |
title_short |
Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection |
title_full |
Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection |
title_fullStr |
Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection |
title_full_unstemmed |
Association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis C virus infection |
title_sort |
association between risk factors, basal viral load, virus genotype and the degree of liver fibrosis with the response to the therapy in patients with chronic hepatitis c virus infection |
publisher |
Military Health Department, Ministry of Defance, Serbia |
series |
Vojnosanitetski Pregled |
issn |
0042-8450 |
publishDate |
2015-01-01 |
description |
Background/Aim. Hepatitis C is an important sociomedical problem worldwide
due to frequent progression to chronic disease, occurrence of liver
cirrhosis and hepatocellular carcinoma. Standard pegylated interferon alfa 2a
plus ribavirin therapy results in resolution of infection only in 50% of
patients. The aim of this study was to determine the association of various
factors with response to the therapy in patients with chronic hepatitis C
virus (HCV) infection. Age and sex of patients, inoculation risk factors,
histopathological changes in the liver, viral load and HCV genotype were
analyzed. Methods. The study included a group of 121 patients with chronic
HCV infection. The treatment was carried out 24 weeks for virus genotype 2
and 3, and 48 weeks for genotype 1 and 4. The degree of histopathological
changes in the liver was determined by hematoxylin and eosin staining,
whereas polimerase chain reaction was used for HCV genotyping. Results. In
the group of non-responding patients genotype 1 was represented with 100%,
while in the other groups, although predominantly present, its percentage
was lower. Unresponsiveness to therapy and relapse of disease were associated
with higher viral load and advanced fibrosis. Intravenous use of psychoactive
substances, as a risk factor, was present in a high percentage in the group
of patients with sustained response, while blood transfusion and dialysis
were leading risk factors in the group of relapse responders and
non-responders. Conclusion. The results of our study showed that the
treatment outcome of chronic HCV infection was associated with baseline HCV
ribonucleic acid, HCV genotype, route of infection and the degree of
histopathological changes in the liver. [Projekat Ministarstva nauke
Republike Srbije, br. III41010] |
topic |
hepatitis C hepatitis, chronic treatment outcome risk factors genotype histological techniques disease transmission, infections |
url |
http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501506505V.pdf |
work_keys_str_mv |
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