Dual Influence of Endocannabinoids on Long-Term Potentiation of Synaptic Transmission

Dual Influence of Endocannabinoids on Long-Term Potentiation of Synaptic Transmission

Cannabinoid receptor 1 (CB1R) is widely distributed in the central nervous system, in excitatory and inhibitory neurons, and in astrocytes. CB1R agonists impair cognition and prevent long-term potentiation (LTP) of synaptic transmission, but the influence of endogenously formed cannabinoids (eCBs) o...

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Bibliographic Details
Main Authors: Armando Silva-Cruz, Mattias Carlström, Joaquim A. Ribeiro, Ana M. Sebastião
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Pharmacology
Subjects:
endocannabinoids
cannabinoid CB1 receptor
long-term potentiation
adenosine A1 receptor
hippocampus
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00921/full

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