Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection

Activation of calcium sensing receptor (CaSR) contributes to cardiac injury, but the underlying mechanism has not yet been examined. Astragaloside IV (AsIV) was previously reported to exhibit protective effects against various myocardial injuries. The aim of the present study was to investigate the...

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Bibliographic Details
Main Authors: Meili Lu, Bin Leng, Xin He, Zhen Zhang, Hongxin Wang, Futian Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
astragaloside IV
calcium sensing receptor
cardiac hypertrophy
apoptosis
calcineurin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01163/full

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