4‐Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen‐induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts

4‐Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen‐induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts

Abstract 4‐Phenylbutyric acid (4‐PBA) exerts potent pharmacological effects, including anti‐inflammatory properties, via inhibition of endoplasmic reticulum (ER) stress. However, it is not known whether 4‐PBA attenuates the severity of rheumatoid arthritis. The present study aimed to determine wheth...

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Bibliographic Details
Main Authors: Yunjung Choi, Eun‐Gyeong Lee, Ji‐Hyeon Jeong, Wan‐Hee Yoo
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
4‐Phenylbutyric acid
collagen‐induced arthritis
endoplasmic reticulum
rheumatoid arthritis
synovial fibroblast
Online Access:https://doi.org/10.1002/kjm2.12376

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