Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma
The intrinsic drivers of glioblastoma (GBM) migration are still poorly understood. Here the authors purify GBM stem cells (GSCs) from patients and profile chromatin accessibility in these cells, identifying TEAD1 as a regulator of migration in human glioblastoma.
Main Authors: | Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M. Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H. Friedel, Elena Zaslavsky, Nadejda M. Tsankova |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-06258-2 |
Similar Items
-
Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties
by: Jessica Tome-Garcia, et al.
Published: (2017-05-01) -
Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironmentResearch in context
by: Rut Tejero, et al.
Published: (2019-04-01) -
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
by: Yong Huang, et al.
Published: (2021-01-01) -
Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex
by: Hung Yi Kristal Kaan, et al.
Published: (2017-05-01) -
Tead and AP1 Coordinate Transcription and Motility
by: Xiangfan Liu, et al.
Published: (2016-02-01)