A <it>pri-miR-218</it> variant and risk of cervical carcinoma in Chinese women

• Main Authors: Shi Ting-Yan, Chen Xiao-Jun, Zhu Mei-Ling, Wang Meng-Yun, He Jing, Yu Ke-Da, Shao Zhi-Ming, Sun Meng-Hong, Zhou Xiao-Yan, Cheng Xi, Wu Xiaohua, Wei Qingyi
• Format: Article
• Language: English
• Published: BMC 2013-01-01
• Series: BMC Cancer
• Subjects: Case–control study; Cervical cancer; <it>LAMB3-miR-218</it> pathway; Polymorphism; Genetic susceptibility
• Online Access: http://www.biomedcentral.com/1471-2407/13/19

<p>Abstract</p> <p>Background</p> <p>MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma.</p> <p>Methods</p> <p>In this case–control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two <it>miR-218</it>-related SNPs involved in the <it>LAMB3-miR-218</it> pathway and the risk of cervical carcinoma in Eastern Chinese women.</p> <p>Results</p> <p>We found that the <it>pri-miR-218</it> rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, <it>P</it>=0.015). However, this association was not observed for the <it>miR-218</it> binding site SNP (rs2566) on <it>LAMB3</it>. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma.</p> <p>Conclusions</p> <p>The <it>pri-miR-218</it> rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.</p>