Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival

Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival

Summary: Human pluripotent stem cells (hPSCs) are susceptible to numerical and structural chromosomal alterations during long-term culture. We show that mitotic errors occur frequently in hPSCs and that prometaphase arrest leads to very rapid apoptosis in undifferentiated but not in differentiated c...

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Main Authors: Jing Zhang, Adam J. Hirst, Fuyu Duan, Hui Qiu, Rujin Huang, Ying Ji, Lufeng Bai, Fengzhi Zhang, Darren Robinson, Mark Jones, Le Li, Peizhe Wang, Peng Jiang, Peter W. Andrews, Ivana Barbaric, Jie Na
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119300153

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