STUDY OF THE CHEMICAL COMPOSITION OF THE ESSENTIAL OIL RECEIVED FROM HERBAL DRUG PRODUCTS OF SHIZANDRA CHINESIS’ SEEDS (<i>SCHISÁNDRA CHINÉNSIS </i>BAILL.) BY THE CHROMATOMASS-SPECTROMETRY METHOD

• Main Authors: N. V. Kartashova, I. A. Samylina, A. V. Strelyaeva, R. M. Kuznetsov
• Format: Article
• Language: Russian
• Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
• Series: Разработка и регистрация лекарственных средств
• Subjects: schizandra chinensis; chromatography; component composition; tincture; schizandrin
• Online Access: https://www.pharmjournal.ru/jour/article/view/518

The analysis of component composition of the Schizandra chinensis has been carried out. Fruits (Fructus Schisandre) and seeds (Semina Schisandre) of Schisandra Chinese serve as medicinal plant raw materials. The chromatography analysis of component composition of alcoholic tincture of fructus of the Schizandra chinensis and of alcoholic tincture of semina of the Schizandra chinensis has been carried. The existence of major and minor components has been established by the results of chromatography analysis made with Agilent Technologies device. Qualitative and quantitative distinction between galenicals has been revealed with the help of ChemStationE 02.00 software and library for Mass Spectrometry NIST-05. In galenicals terpenoids, phenylpropanoids, threternenal saponins, carbohydrates, lignans, aminoacids and furanocumarins have been detected. As a result of the analysis of tincture of fruits Schisandra сhinese were detected 36 substances belonging to different classes: alcohols, acids, sugars, ketones, anthracene derivatives, terpenes, ethers and other compounds. The relative percentage of each component was calculated taking into account unidentified peaks. According to the results of the study, it's possible to draw a conclusion about the chemical heterogeneity of the essential oil of Shizandra сhinesis' seeds. The following groups of biologically active substances were found in the essential oil from the Shizandra сhinesis' seeds: terpenoids, phenylpropanoids, triterpene saponins, glycosides, carbohydrates, lignans, amino acids and furanocoumarins.