Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus
BackgroundWe examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM).MethodsA 75-g oral glucose tolerance test (OGTT) was conduc...
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2011-02-01
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doaj-287b99264b634073a01ea221f90250f32020-11-25T01:19:09ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872011-02-01351586410.4093/dmj.2011.35.1.582777Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes MellitusSung Hoon YuBongjun ChoYejin LeeEunhye KimSung Hee ChoiSoo LimKa Hee YiYoung Joo ParkKyong Soo ParkHak Chul JangBackgroundWe examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM).MethodsA 75-g oral glucose tolerance test (OGTT) was conducted on 34 women with pGDM. In addition, 11 women with normal glucose tolerance, matched for age, height and weight, were also tested. The insulin, GIP, GLP-1, and glucagon concentrations were measured, and their anthropometric and biochemical markers were also measured.ResultsAmong 34 women with pGDM, 18 had normal glucose tolerance, 13 had impaired glucose tolerance (IGT) and 1 had diabetes. No significant differences were found in GLP-1 concentration between the pGDM and control group. However, a significantly high level of glucagon was present in the pGDM group at 30 minutes into the OGTT. The GIP concentration was elevated at 30 minutes and 60 minutes in the pGDM group. With the exception of the 30-minute timepoint, women with IGT had significantly high blood glucose from 0 to 120 minutes. However, there was no significant difference in insulin or GLP-1 concentration. The GIP level was significantly high from 0 to 90 minutes in patients diagnosed with IGT.ConclusionGLP-1 secretion does not differ between pGDM patients and normal women. GIP was elevated, but that does not seem to induce in increase in insulin secretion. Therefore, we conclude that other factors such as heredity and environment play important roles in the development of type 2 diabetes.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-58.pdfGestational diabetes mellitusGlucagonGlucagon-like peptide 1Glucose-dependent insulinotropic polypeptideInsulin secretion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sung Hoon Yu Bongjun Cho Yejin Lee Eunhye Kim Sung Hee Choi Soo Lim Ka Hee Yi Young Joo Park Kyong Soo Park Hak Chul Jang |
spellingShingle |
Sung Hoon Yu Bongjun Cho Yejin Lee Eunhye Kim Sung Hee Choi Soo Lim Ka Hee Yi Young Joo Park Kyong Soo Park Hak Chul Jang Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus Diabetes & Metabolism Journal Gestational diabetes mellitus Glucagon Glucagon-like peptide 1 Glucose-dependent insulinotropic polypeptide Insulin secretion |
author_facet |
Sung Hoon Yu Bongjun Cho Yejin Lee Eunhye Kim Sung Hee Choi Soo Lim Ka Hee Yi Young Joo Park Kyong Soo Park Hak Chul Jang |
author_sort |
Sung Hoon Yu |
title |
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus |
title_short |
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus |
title_full |
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus |
title_fullStr |
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus |
title_full_unstemmed |
Insulin Secretion and Incretin Hormone Concentration in Women with Previous Gestational Diabetes Mellitus |
title_sort |
insulin secretion and incretin hormone concentration in women with previous gestational diabetes mellitus |
publisher |
Korean Diabetes Association |
series |
Diabetes & Metabolism Journal |
issn |
2233-6079 2233-6087 |
publishDate |
2011-02-01 |
description |
BackgroundWe examined the change in the levels of incretin hormone and effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) on insulin secretion in women with previous gestational diabetes (pGDM).MethodsA 75-g oral glucose tolerance test (OGTT) was conducted on 34 women with pGDM. In addition, 11 women with normal glucose tolerance, matched for age, height and weight, were also tested. The insulin, GIP, GLP-1, and glucagon concentrations were measured, and their anthropometric and biochemical markers were also measured.ResultsAmong 34 women with pGDM, 18 had normal glucose tolerance, 13 had impaired glucose tolerance (IGT) and 1 had diabetes. No significant differences were found in GLP-1 concentration between the pGDM and control group. However, a significantly high level of glucagon was present in the pGDM group at 30 minutes into the OGTT. The GIP concentration was elevated at 30 minutes and 60 minutes in the pGDM group. With the exception of the 30-minute timepoint, women with IGT had significantly high blood glucose from 0 to 120 minutes. However, there was no significant difference in insulin or GLP-1 concentration. The GIP level was significantly high from 0 to 90 minutes in patients diagnosed with IGT.ConclusionGLP-1 secretion does not differ between pGDM patients and normal women. GIP was elevated, but that does not seem to induce in increase in insulin secretion. Therefore, we conclude that other factors such as heredity and environment play important roles in the development of type 2 diabetes. |
topic |
Gestational diabetes mellitus Glucagon Glucagon-like peptide 1 Glucose-dependent insulinotropic polypeptide Insulin secretion |
url |
http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-58.pdf |
work_keys_str_mv |
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