Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study
It has been suggested that dorsal and ventral pathways support distinct aspects of language processing. Yet, the full extent of their involvement and their inter-regional connectivity in visual word recognition is still unknown. Studies suggest that they might reflect the dual-route model of reading...
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doaj-288612227288419198982b87921608052020-11-25T02:34:37ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-06-011110.3389/fnhum.2017.00325236139Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling StudyMarcela Perrone-Bertolotti0Louise Kauffmann1Louise Kauffmann2Cédric Pichat3Juan R. Vidal4Monica Baciu5Department of Psychology, Université Grenoble Alpes, CNRS, LPNC UMR 51055105Grenoble, FranceDepartment of Psychology, Université Grenoble Alpes, CNRS, LPNC UMR 51055105Grenoble, FranceNeural Mechanisms of Human Communication Research group, Max Planck Institute for Human Cognitive and Brain SciencesLeipzig, GermanyDepartment of Psychology, Université Grenoble Alpes, CNRS, LPNC UMR 51055105Grenoble, FranceDepartment of Psychology, Université Grenoble Alpes, CNRS, LPNC UMR 51055105Grenoble, FranceDepartment of Psychology, Université Grenoble Alpes, CNRS, LPNC UMR 51055105Grenoble, FranceIt has been suggested that dorsal and ventral pathways support distinct aspects of language processing. Yet, the full extent of their involvement and their inter-regional connectivity in visual word recognition is still unknown. Studies suggest that they might reflect the dual-route model of reading, with the dorsal pathway more involved in grapho-phonological conversion during phonological tasks, and the ventral pathway performing lexico-semantic access during semantic tasks. Furthermore, this subdivision is also suggested at the level of the inferior frontal cortex, involving ventral and dorsal parts for lexico-semantic and phonological processing, respectively. In the present study, we assessed inter-regional brain connectivity and task-induced modulations of brain activity during a phoneme detection and semantic categorization tasks, using fMRI in healthy subject. We used a dynamic causal modeling approach to assess inter-regional connectivity and task demand modulation within the dorsal and ventral pathways, including the following network components: the ventral occipito-temporal cortex (vOTC; dorsal and ventral), the superior temporal gyrus (STG; dorsal), the dorsal inferior frontal gyrus (dIFG; dorsal), and the ventral IFG (vIFG; ventral). We report three distinct inter-regional interactions supporting orthographic information transfer from vOTC to other language regions (vOTC -> STG, vOTC -> vIFG and vOTC -> dIFG) regardless of task demands. Moreover, we found that (a) during semantic processing (direct ventral pathway) the vOTC -> vIFG connection strength specifically increased and (b) a lack of modulation of the vOTC -> dIFG connection strength by the task that could suggest a more general involvement of the dorsal pathway during visual word recognition. Results are discussed in terms of anatomo-functional connectivity of visual word recognition network.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00325/fulldorsal streamventral streamphonologysemanticventral occipito-temporal cortexventral inferior frontal cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcela Perrone-Bertolotti Louise Kauffmann Louise Kauffmann Cédric Pichat Juan R. Vidal Monica Baciu |
spellingShingle |
Marcela Perrone-Bertolotti Louise Kauffmann Louise Kauffmann Cédric Pichat Juan R. Vidal Monica Baciu Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study Frontiers in Human Neuroscience dorsal stream ventral stream phonology semantic ventral occipito-temporal cortex ventral inferior frontal cortex |
author_facet |
Marcela Perrone-Bertolotti Louise Kauffmann Louise Kauffmann Cédric Pichat Juan R. Vidal Monica Baciu |
author_sort |
Marcela Perrone-Bertolotti |
title |
Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study |
title_short |
Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study |
title_full |
Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study |
title_fullStr |
Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study |
title_full_unstemmed |
Effective Connectivity between Ventral Occipito-Temporal and Ventral Inferior Frontal Cortex during Lexico-Semantic Processing. A Dynamic Causal Modeling Study |
title_sort |
effective connectivity between ventral occipito-temporal and ventral inferior frontal cortex during lexico-semantic processing. a dynamic causal modeling study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2017-06-01 |
description |
It has been suggested that dorsal and ventral pathways support distinct aspects of language processing. Yet, the full extent of their involvement and their inter-regional connectivity in visual word recognition is still unknown. Studies suggest that they might reflect the dual-route model of reading, with the dorsal pathway more involved in grapho-phonological conversion during phonological tasks, and the ventral pathway performing lexico-semantic access during semantic tasks. Furthermore, this subdivision is also suggested at the level of the inferior frontal cortex, involving ventral and dorsal parts for lexico-semantic and phonological processing, respectively. In the present study, we assessed inter-regional brain connectivity and task-induced modulations of brain activity during a phoneme detection and semantic categorization tasks, using fMRI in healthy subject. We used a dynamic causal modeling approach to assess inter-regional connectivity and task demand modulation within the dorsal and ventral pathways, including the following network components: the ventral occipito-temporal cortex (vOTC; dorsal and ventral), the superior temporal gyrus (STG; dorsal), the dorsal inferior frontal gyrus (dIFG; dorsal), and the ventral IFG (vIFG; ventral). We report three distinct inter-regional interactions supporting orthographic information transfer from vOTC to other language regions (vOTC -> STG, vOTC -> vIFG and vOTC -> dIFG) regardless of task demands. Moreover, we found that (a) during semantic processing (direct ventral pathway) the vOTC -> vIFG connection strength specifically increased and (b) a lack of modulation of the vOTC -> dIFG connection strength by the task that could suggest a more general involvement of the dorsal pathway during visual word recognition. Results are discussed in terms of anatomo-functional connectivity of visual word recognition network. |
topic |
dorsal stream ventral stream phonology semantic ventral occipito-temporal cortex ventral inferior frontal cortex |
url |
http://journal.frontiersin.org/article/10.3389/fnhum.2017.00325/full |
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