Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection
Here, following a patient with severe acute Pseudomonas aeruginosa infection, the authors combine comprehensive isolate characterization from lung and gut samples (>100 isolates) and patient clinical data to provide insights into bacterial responses to antibiotic therapy.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22814-9 |
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doaj-288e3c2784b04e7b8be0262d7398b88b2021-05-02T11:12:46ZengNature Publishing GroupNature Communications2041-17232021-04-0112111210.1038/s41467-021-22814-9Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infectionRachel Wheatley0Julio Diaz Caballero1Natalia Kapel2Fien H. R. de Winter3Pramod Jangir4Angus Quinn5Ester del Barrio-Tofiño6Carla López-Causapé7Jessica Hedge8Gabriel Torrens9Thomas Van der Schalk10Basil Britto Xavier11Felipe Fernández-Cuenca12Angel Arenzana13Claudia Recanatini14Leen Timbermont15Frangiscos Sifakis16Alexey Ruzin17Omar Ali18Christine Lammens19Herman Goossens20Jan Kluytmans21Samir Kumar-Singh22Antonio Oliver23Surbhi Malhotra-Kumar24Craig MacLean25University of Oxford, Department of ZoologyUniversity of Oxford, Department of ZoologyUniversity of Oxford, Department of ZoologyLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpUniversity of Oxford, Department of ZoologyUniversity of Oxford, Department of ZoologyHospital Universitario Son EspasesHospital Universitario Son EspasesUniversity of Oxford, Department of ZoologyHospital Universitario Son EspasesLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpDepartamento de Medicina, Universidad de SevillaDepartamento de Medicina, Universidad de SevillaJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpBoehringer Ingelheim Pharmaceuticals, IncMicrobial Sciences, BioPharmaceuticals R&D, AstraZenecaMicrobial Sciences, BioPharmaceuticals R&D, AstraZenecaLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht UniversityLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpHospital Universitario Son EspasesLaboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of AntwerpUniversity of Oxford, Department of ZoologyHere, following a patient with severe acute Pseudomonas aeruginosa infection, the authors combine comprehensive isolate characterization from lung and gut samples (>100 isolates) and patient clinical data to provide insights into bacterial responses to antibiotic therapy.https://doi.org/10.1038/s41467-021-22814-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Rachel Wheatley Julio Diaz Caballero Natalia Kapel Fien H. R. de Winter Pramod Jangir Angus Quinn Ester del Barrio-Tofiño Carla López-Causapé Jessica Hedge Gabriel Torrens Thomas Van der Schalk Basil Britto Xavier Felipe Fernández-Cuenca Angel Arenzana Claudia Recanatini Leen Timbermont Frangiscos Sifakis Alexey Ruzin Omar Ali Christine Lammens Herman Goossens Jan Kluytmans Samir Kumar-Singh Antonio Oliver Surbhi Malhotra-Kumar Craig MacLean |
| spellingShingle |
Rachel Wheatley Julio Diaz Caballero Natalia Kapel Fien H. R. de Winter Pramod Jangir Angus Quinn Ester del Barrio-Tofiño Carla López-Causapé Jessica Hedge Gabriel Torrens Thomas Van der Schalk Basil Britto Xavier Felipe Fernández-Cuenca Angel Arenzana Claudia Recanatini Leen Timbermont Frangiscos Sifakis Alexey Ruzin Omar Ali Christine Lammens Herman Goossens Jan Kluytmans Samir Kumar-Singh Antonio Oliver Surbhi Malhotra-Kumar Craig MacLean Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection Nature Communications |
| author_facet |
Rachel Wheatley Julio Diaz Caballero Natalia Kapel Fien H. R. de Winter Pramod Jangir Angus Quinn Ester del Barrio-Tofiño Carla López-Causapé Jessica Hedge Gabriel Torrens Thomas Van der Schalk Basil Britto Xavier Felipe Fernández-Cuenca Angel Arenzana Claudia Recanatini Leen Timbermont Frangiscos Sifakis Alexey Ruzin Omar Ali Christine Lammens Herman Goossens Jan Kluytmans Samir Kumar-Singh Antonio Oliver Surbhi Malhotra-Kumar Craig MacLean |
| author_sort |
Rachel Wheatley |
| title |
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection |
| title_short |
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection |
| title_full |
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection |
| title_fullStr |
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection |
| title_full_unstemmed |
Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection |
| title_sort |
rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute pseudomonas aeruginosa infection |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-04-01 |
| description |
Here, following a patient with severe acute Pseudomonas aeruginosa infection, the authors combine comprehensive isolate characterization from lung and gut samples (>100 isolates) and patient clinical data to provide insights into bacterial responses to antibiotic therapy. |
| url |
https://doi.org/10.1038/s41467-021-22814-9 |
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