| Summary: | Objective: To investigate the correlation between plasma hydrogen sulfide (H2S),
homocysteine (Hcy), folic acid and vitamin B12 in patients with acute promyelocytic leukemia
(APL) before and after treatment. Methods: A total of 26 hospitalized patients with APL were
randomly selected as case group and 26 healthy persons as control group. The concentration
of H2S, Hcy and folic acid in plasma of case group and control group were measured,
respectively. The statistically significant difference was investigated by comparing the acute
onset phase and clinical remission of case group with those of healthy control group. Results:
The concentration of H2S and Hcy of plasma in patients of case group during acute onset phase
significantly increased, and concentration of folic acid significantly decreased, and there were
both statistically significant differences as compared with those during clinical remission and
those of control group (P<0.01). The concentration of H2S and Hcy of plasma in patients of
case group during clinical remission after treatment decreased, and concentration of folic acid
increased. The result was close to that of healthy control group, and there was no statistically
significant difference (P>0.05). The change in concentration of plasma H2S was positively
correlated with that of Hcy and negatively correlated with that of folic acid in patients of case
group before and after treatment. Conclusions: The increase of plasma H2S in patients with
APL may be related to the changes in concentration of Hcy and folic acid.
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