A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and media...

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Main Authors:	Xueyi Shen, David M. Howard, Mark J. Adams, W. David Hill, Toni-Kim Clarke, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Ian J. Deary, Heather C. Whalley, Andrew M. McIntosh
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16022-0

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spelling	doaj-28a072e158aa43dd8062b55e678c77e22021-05-11T08:14:34ZengNature Publishing GroupNature Communications2041-17232020-05-0111111610.1038/s41467-020-16022-0A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK BiobankXueyi Shen0David M. Howard1Mark J. Adams2W. David Hill3Toni-Kim Clarke4Major Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumIan J. Deary5Heather C. Whalley6Andrew M. McIntosh7Division of Psychiatry, University of EdinburghDivision of Psychiatry, University of EdinburghDivision of Psychiatry, University of EdinburghCentre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghDivision of Psychiatry, University of EdinburghCentre for Cognitive Ageing and Cognitive Epidemiology, University of EdinburghDivision of Psychiatry, University of EdinburghDivision of Psychiatry, University of EdinburghDepression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.https://doi.org/10.1038/s41467-020-16022-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xueyi Shen David M. Howard Mark J. Adams W. David Hill Toni-Kim Clarke Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Ian J. Deary Heather C. Whalley Andrew M. McIntosh
spellingShingle	Xueyi Shen David M. Howard Mark J. Adams W. David Hill Toni-Kim Clarke Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Ian J. Deary Heather C. Whalley Andrew M. McIntosh A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank Nature Communications
author_facet	Xueyi Shen David M. Howard Mark J. Adams W. David Hill Toni-Kim Clarke Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium Ian J. Deary Heather C. Whalley Andrew M. McIntosh
author_sort	Xueyi Shen
title	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_short	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_full	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_fullStr	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_full_unstemmed	A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
title_sort	phenome-wide association and mendelian randomisation study of polygenic risk for depression in uk biobank
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.
url	https://doi.org/10.1038/s41467-020-16022-0
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A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

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