Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones
Objective: to evaluate the effects of the immunostimulants panavir and derinate on a postresuscitation process in animals of different sexes.Material and methods. The investigation was made on 200—250-g albino rats of both sexes in winter. Circulation was stopped by intrathoracic ligation of ...
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Russian Academy of Medical Sciences
2014-06-01
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doaj-28a0d708d04b4461a45220b2f3c75abb2021-07-28T21:21:54ZrusRussian Academy of Medical SciencesObŝaâ Reanimatologiâ1813-97792411-71102014-06-0110151110.15360/1813-9779-2014-1-5-111329Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid HormonesYu. V. Zarzhetsky0V. V. Moroz1A. V. Volkov2V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowV. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowV. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowObjective: to evaluate the effects of the immunostimulants panavir and derinate on a postresuscitation process in animals of different sexes.Material and methods. The investigation was made on 200—250-g albino rats of both sexes in winter. Circulation was stopped by intrathoracic ligation of the cardiac vascular bundle in ether<anesthetized rats for 10 min. Functional recovery of the central nervous system and changes in sex steroid hormones were assessed in the postresuscitation period. The investigation used two immunoactive drugs: panavir 0.02 mg/kg and derinate 150 μg/kg. Either agent was intramuscularly injected twice: at 3 0 minutes after resuscitation and on the following day.Results. The injected drugs were ascertained to have a positive effect on functional recovery of the brain. Their use was shown to modify the sex steroid hormone profiles in both males and females in the early postresuscitation period.Conclusion. The findings suggest that the immunoactive agents are able to affect the nervous and endocrine systems in critical conditions.https://www.reanimatology.com/rmt/article/view/1329ischemia, central nervous system, immunoactive drugs, steroid hormones, sex differences |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Yu. V. Zarzhetsky V. V. Moroz A. V. Volkov |
spellingShingle |
Yu. V. Zarzhetsky V. V. Moroz A. V. Volkov Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones Obŝaâ Reanimatologiâ ischemia, central nervous system, immunoactive drugs, steroid hormones, sex differences |
author_facet |
Yu. V. Zarzhetsky V. V. Moroz A. V. Volkov |
author_sort |
Yu. V. Zarzhetsky |
title |
Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones |
title_short |
Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones |
title_full |
Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones |
title_fullStr |
Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones |
title_full_unstemmed |
Effect of Immunoactive Drugs on Postresuscitation Processes in the Brain and Steroid Hormones |
title_sort |
effect of immunoactive drugs on postresuscitation processes in the brain and steroid hormones |
publisher |
Russian Academy of Medical Sciences |
series |
Obŝaâ Reanimatologiâ |
issn |
1813-9779 2411-7110 |
publishDate |
2014-06-01 |
description |
Objective: to evaluate the effects of the immunostimulants panavir and derinate on a postresuscitation process in animals of different sexes.Material and methods. The investigation was made on 200—250-g albino rats of both sexes in winter. Circulation was stopped by intrathoracic ligation of the cardiac vascular bundle in ether<anesthetized rats for 10 min. Functional recovery of the central nervous system and changes in sex steroid hormones were assessed in the postresuscitation period. The investigation used two immunoactive drugs: panavir 0.02 mg/kg and derinate 150 μg/kg. Either agent was intramuscularly injected twice: at 3 0 minutes after resuscitation and on the following day.Results. The injected drugs were ascertained to have a positive effect on functional recovery of the brain. Their use was shown to modify the sex steroid hormone profiles in both males and females in the early postresuscitation period.Conclusion. The findings suggest that the immunoactive agents are able to affect the nervous and endocrine systems in critical conditions. |
topic |
ischemia, central nervous system, immunoactive drugs, steroid hormones, sex differences |
url |
https://www.reanimatology.com/rmt/article/view/1329 |
work_keys_str_mv |
AT yuvzarzhetsky effectofimmunoactivedrugsonpostresuscitationprocessesinthebrainandsteroidhormones AT vvmoroz effectofimmunoactivedrugsonpostresuscitationprocessesinthebrainandsteroidhormones AT avvolkov effectofimmunoactivedrugsonpostresuscitationprocessesinthebrainandsteroidhormones |
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1721259783881752576 |