Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study
Object: The purpose of our study was to investigate the microstructural changes of the medial temporal cortex in mild cognitive impairment (MCI) patients with cerebral small vascular disease (cSVD) using diffusion kurtosis imaging (DKI) and to examine whether DKI parameters are correlated with MCI.M...
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doaj-28b07a0573514173bc65b63690955a572020-11-25T00:44:54ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-01-011010.3389/fneur.2019.01378491148Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging StudyDongtao Liu0Kun Li1Xiangke Ma2Yue Li3Qiao Bu4Zhenyu Pan5Xiang Feng6Qinglei Shi7Lichun Zhou8Wenli Hu9Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaMR Scientific Marketing, Diagnosis Imaging, Siemens Healthineers China, Beijing, ChinaMR Scientific Marketing, Diagnosis Imaging, Siemens Healthineers China, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, ChinaObject: The purpose of our study was to investigate the microstructural changes of the medial temporal cortex in mild cognitive impairment (MCI) patients with cerebral small vascular disease (cSVD) using diffusion kurtosis imaging (DKI) and to examine whether DKI parameters are correlated with MCI.Method: A total of 82 cSVD patients admitted to the Department of Neurology Beijing Chaoyang Hospital, Capital Medical University, were retrospectively enrolled in this study. The Montreal cognitive assessment scale (MoCA) score was used to assess overall cognitive function. According to the presence or absence of MCI, these patients were divided into an MCI group (n = 48) and a non-MCI group (n = 34). The general clinical data of the two groups were collected and analyzed. The regions of interest (ROIs) in the medial temporal cortex were selected for investigation. The averaged values of DKI parameters were measured in each ROI and compared between the two groups, and the correlations between DKI parameters and MoCA score and between diffusion and kurtosis parameters were examined.Results: Compared to the non-MCI group, MCI patients showed significantly increased mean diffusion (MD) and radial diffusion (RD) and significantly decreased mean kurtosis (MK) in the left hippocampus (P = 0.005, 0.006, 0.002, respectively). In the left hippocampus, fractional anisotropy (FA), MK, radial kurtosis (RK), and kurtosis fractional anisotropy (KFA) showed significantly positive correlations with MoCA score (r = 0.374, 0.37, 0.392, 0.242, respectively, all P < 0.05), while MK and RD were negatively correlated with MoCA score (r = −0.227, −0.255, respectively, both P < 0.05). In the left parahippocampal region, axial kurtosis (AK) and KFA were positively correlated with MoCA score (r = 0.228, 0.282, respectively, both P < 0.05), while RK was positively correlated with MoCA score in the right parahippocampal region (r = 0.231, P < 0.05). Significant correlations of MD with MK, RD with RK, and FA with KFA were observed in the medial temporal cortex (r = −0.254, −0.395, 0.807, respectively, all P < 0.05) but not of axial diffusion (AD) with AK.Conclusion: The DKI technique can be used to observe microstructural changes of the medial temporal cortex in MCI patients with cSVD. The DKI-derived parameters might be a feasible means of evaluating patients with MCI.https://www.frontiersin.org/article/10.3389/fneur.2019.01378/fullmild cognitive impairmentcerebral small vascular diseasemedial temporal cortexdiffusion kurtosis imagingchanges |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dongtao Liu Kun Li Xiangke Ma Yue Li Qiao Bu Zhenyu Pan Xiang Feng Qinglei Shi Lichun Zhou Wenli Hu |
spellingShingle |
Dongtao Liu Kun Li Xiangke Ma Yue Li Qiao Bu Zhenyu Pan Xiang Feng Qinglei Shi Lichun Zhou Wenli Hu Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study Frontiers in Neurology mild cognitive impairment cerebral small vascular disease medial temporal cortex diffusion kurtosis imaging changes |
author_facet |
Dongtao Liu Kun Li Xiangke Ma Yue Li Qiao Bu Zhenyu Pan Xiang Feng Qinglei Shi Lichun Zhou Wenli Hu |
author_sort |
Dongtao Liu |
title |
Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study |
title_short |
Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study |
title_full |
Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study |
title_fullStr |
Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study |
title_full_unstemmed |
Correlations Between the Microstructural Changes of the Medial Temporal Cortex and Mild Cognitive Impairment in Patients With Cerebral Small Vascular Disease (cSVD): A Diffusion Kurtosis Imaging Study |
title_sort |
correlations between the microstructural changes of the medial temporal cortex and mild cognitive impairment in patients with cerebral small vascular disease (csvd): a diffusion kurtosis imaging study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-01-01 |
description |
Object: The purpose of our study was to investigate the microstructural changes of the medial temporal cortex in mild cognitive impairment (MCI) patients with cerebral small vascular disease (cSVD) using diffusion kurtosis imaging (DKI) and to examine whether DKI parameters are correlated with MCI.Method: A total of 82 cSVD patients admitted to the Department of Neurology Beijing Chaoyang Hospital, Capital Medical University, were retrospectively enrolled in this study. The Montreal cognitive assessment scale (MoCA) score was used to assess overall cognitive function. According to the presence or absence of MCI, these patients were divided into an MCI group (n = 48) and a non-MCI group (n = 34). The general clinical data of the two groups were collected and analyzed. The regions of interest (ROIs) in the medial temporal cortex were selected for investigation. The averaged values of DKI parameters were measured in each ROI and compared between the two groups, and the correlations between DKI parameters and MoCA score and between diffusion and kurtosis parameters were examined.Results: Compared to the non-MCI group, MCI patients showed significantly increased mean diffusion (MD) and radial diffusion (RD) and significantly decreased mean kurtosis (MK) in the left hippocampus (P = 0.005, 0.006, 0.002, respectively). In the left hippocampus, fractional anisotropy (FA), MK, radial kurtosis (RK), and kurtosis fractional anisotropy (KFA) showed significantly positive correlations with MoCA score (r = 0.374, 0.37, 0.392, 0.242, respectively, all P < 0.05), while MK and RD were negatively correlated with MoCA score (r = −0.227, −0.255, respectively, both P < 0.05). In the left parahippocampal region, axial kurtosis (AK) and KFA were positively correlated with MoCA score (r = 0.228, 0.282, respectively, both P < 0.05), while RK was positively correlated with MoCA score in the right parahippocampal region (r = 0.231, P < 0.05). Significant correlations of MD with MK, RD with RK, and FA with KFA were observed in the medial temporal cortex (r = −0.254, −0.395, 0.807, respectively, all P < 0.05) but not of axial diffusion (AD) with AK.Conclusion: The DKI technique can be used to observe microstructural changes of the medial temporal cortex in MCI patients with cSVD. The DKI-derived parameters might be a feasible means of evaluating patients with MCI. |
topic |
mild cognitive impairment cerebral small vascular disease medial temporal cortex diffusion kurtosis imaging changes |
url |
https://www.frontiersin.org/article/10.3389/fneur.2019.01378/full |
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