The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm
Summary: Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome v...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
|
Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220311123 |
id |
doaj-28bb8b624ea44a3596b0a2f38edf4c4f |
---|---|
record_format |
Article |
spelling |
doaj-28bb8b624ea44a3596b0a2f38edf4c4f2021-01-24T04:28:42ZengElsevieriScience2589-00422021-01-01241101915The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasmSiyuan Zhang0Fan Xin1Xiaobo Zhang2College of Life Sciences, Laboratory for Marine Biology and Biotechnology of Pilot National Laboratory for Marine Science and Technology (Qingdao) and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhejiang University, Hangzhou 310058, People's Republic of ChinaCollege of Life Sciences, Laboratory for Marine Biology and Biotechnology of Pilot National Laboratory for Marine Science and Technology (Qingdao) and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhejiang University, Hangzhou 310058, People's Republic of ChinaCollege of Life Sciences, Laboratory for Marine Biology and Biotechnology of Pilot National Laboratory for Marine Science and Technology (Qingdao) and Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhejiang University, Hangzhou 310058, People's Republic of China; Corresponding authorSummary: Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells.http://www.sciencedirect.com/science/article/pii/S2589004220311123Human MetabolismMolecular BiologyVirology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siyuan Zhang Fan Xin Xiaobo Zhang |
spellingShingle |
Siyuan Zhang Fan Xin Xiaobo Zhang The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm iScience Human Metabolism Molecular Biology Virology |
author_facet |
Siyuan Zhang Fan Xin Xiaobo Zhang |
author_sort |
Siyuan Zhang |
title |
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_short |
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_full |
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_fullStr |
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_full_unstemmed |
The compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
title_sort |
compound packaged in virions is the key to trigger host glycolysis machinery for virus life cycle in the cytoplasm |
publisher |
Elsevier |
series |
iScience |
issn |
2589-0042 |
publishDate |
2021-01-01 |
description |
Summary: Viruses depend on the host metabolic machinery to complete their life cycle in the host cytoplasm. However, the key viral factors initiating the host machinery after the virus enters the cytoplasm remain unclear. Here, we found that compounds packaged in the virions of white spot syndrome virus, such as palmitic amide, could trigger the viral life cycle in the host cytoplasm. Palmitic amide promoted virus infection by enhancing host glycolysis by binding to triosephosphate isomerase to enhance its enzymatic activity. The glycolysis enhancement resulted in lactate accumulation, thereby promoting hypoxia-inducible factor 1 (HIF-1) expression. HIF-1 upregulation further enhanced glycolysis, which in turn promoted virus infection. Therefore, our study presented novel insight into the initiation of the virus life cycle in host cells. |
topic |
Human Metabolism Molecular Biology Virology |
url |
http://www.sciencedirect.com/science/article/pii/S2589004220311123 |
work_keys_str_mv |
AT siyuanzhang thecompoundpackagedinvirionsisthekeytotriggerhostglycolysismachineryforviruslifecycleinthecytoplasm AT fanxin thecompoundpackagedinvirionsisthekeytotriggerhostglycolysismachineryforviruslifecycleinthecytoplasm AT xiaobozhang thecompoundpackagedinvirionsisthekeytotriggerhostglycolysismachineryforviruslifecycleinthecytoplasm AT siyuanzhang compoundpackagedinvirionsisthekeytotriggerhostglycolysismachineryforviruslifecycleinthecytoplasm AT fanxin compoundpackagedinvirionsisthekeytotriggerhostglycolysismachineryforviruslifecycleinthecytoplasm AT xiaobozhang compoundpackagedinvirionsisthekeytotriggerhostglycolysismachineryforviruslifecycleinthecytoplasm |
_version_ |
1724326730700685312 |