Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

Accelerating Biomanufacturing by Modeling of Continuous Bioprocessing—Piloting Case Study of Monoclonal Antibody Manufacturing

An experimental feasibility study on continuous bioprocessing in pilot-scale of 1 L/day cell supernatant, that is, about 150 g/year product (monoclonal antibody) based on CHO (Chinese hamster ovary) cells for model validation is performed for about six weeks including preparation, start-up, batch, a...

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Bibliographic Details
Main Authors:	Martin Kornecki, Axel Schmidt, Lara Lohmann, Maximilian Huter, Fabian Mestmäcker, Leon Klepzig, Mourad Mouellef, Steffen Zobel-Roos, Jochen Strube
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Processes
Subjects:	continuous bioprocessing (CBP) model validation antibodies quality-by-design (QbD) process analytical technology (PAT)
Online Access:	https://www.mdpi.com/2227-9717/7/8/495

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