The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis

Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly...

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Main Authors: Jiang Wu, Weiwei Zhang, Qian Ran, Yang Xiang, Jiang F. Zhong, Shengwen Calvin Li, Zhongjun Li
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2018/1540148
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spelling doaj-28c289ee215b4751852aed0f3b1f81dd2020-11-24T23:51:05ZengHindawi LimitedStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/15401481540148The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to HematopoiesisJiang Wu0Weiwei Zhang1Qian Ran2Yang Xiang3Jiang F. Zhong4Shengwen Calvin Li5Zhongjun Li6Department of Blood Transfusion, Lab of Radiation Biology, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, ChinaDepartment of Blood Transfusion, Lab of Radiation Biology, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, ChinaDepartment of Blood Transfusion, Lab of Radiation Biology, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, ChinaDepartment of Blood Transfusion, Lab of Radiation Biology, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, ChinaDivision of Periodontology, Diagnostic Sciences & Dental Hygiene, and Division of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90089, USACHOC Children’s Hospital Research Institute, University of California, Irvine, 1201 West La Veta Ave, Orange, CA 92868, USADepartment of Blood Transfusion, Lab of Radiation Biology, The Second Affiliated Hospital, Army Medical University, Chongqing 400037, ChinaBone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. Moreover, the differentiation balance of BMSCs is crucial to hematopoiesis. We highlight the negative effects of differentiation bias of BMSCs on hematopoietic recovery after bone marrow transplantation. Keeping the differentiation balance of BMSCs is critical for hematopoietic recovery. This review summarises current understanding about how BMSC differentiation affects hematopoiesis and its potential application in improving hematopoietic recovery after bone marrow transplantation.http://dx.doi.org/10.1155/2018/1540148
collection DOAJ
language English
format Article
sources DOAJ
author Jiang Wu
Weiwei Zhang
Qian Ran
Yang Xiang
Jiang F. Zhong
Shengwen Calvin Li
Zhongjun Li
spellingShingle Jiang Wu
Weiwei Zhang
Qian Ran
Yang Xiang
Jiang F. Zhong
Shengwen Calvin Li
Zhongjun Li
The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
Stem Cells International
author_facet Jiang Wu
Weiwei Zhang
Qian Ran
Yang Xiang
Jiang F. Zhong
Shengwen Calvin Li
Zhongjun Li
author_sort Jiang Wu
title The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
title_short The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
title_full The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
title_fullStr The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
title_full_unstemmed The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
title_sort differentiation balance of bone marrow mesenchymal stem cells is crucial to hematopoiesis
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2018-01-01
description Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. Moreover, the differentiation balance of BMSCs is crucial to hematopoiesis. We highlight the negative effects of differentiation bias of BMSCs on hematopoietic recovery after bone marrow transplantation. Keeping the differentiation balance of BMSCs is critical for hematopoietic recovery. This review summarises current understanding about how BMSC differentiation affects hematopoiesis and its potential application in improving hematopoietic recovery after bone marrow transplantation.
url http://dx.doi.org/10.1155/2018/1540148
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