| Summary: | Objective: To study the effect of Xiao Chaihu Tang combined with intravenous chemotherapy
on tumor markers and immune function in patients with advanced breast cancer. Methods: 76
patients with advanced breast cancer treated in our hospital between May 2012 and November
2015 were collected and divided into the combined treatment group (n=34) who accepted Xiao
Chaihu Tang combined with intravenous chemotherapy and the control group (n=42) who
accepted intravenous chemotherapy alone according to different treatment, and the treatment
cycle was 3 months for both groups. Before treatment and 3 months after treatment, ELISA
method was used to detect serum levels of broad-spectrum tumor markers and breast cancerspecific
tumor markers; flow cytometer was used to detect cellular immune function index
levels, and turbidimetric immunoassay was used to detect humoral immune function index
levels in peripheral blood. Results: Before treatment, differences in serum tumor marker levels
as well as cellular immunity and humoral immunity index levels in peripheral blood were not
statistically significant between two groups of patients (P>0.05); after 3 months of treatment,
broad-spectrum tumor markers carcinoembryonic antigen (CEA), carbohydrate antigen 153
(CA153) and carbohydrate antigen 125 (CA125) levels in serum of combined treatment group
were lower than those of control group, and breast cancer-specific tumor markers insulin-like
growth factor-1 (IGF-1), midkine (MK), soluble E-cadherin (sEC) and thymidine kinase 1
(TK1) levels were lower than those of control group (P<0.05); CD3+ and CD4+ T lymphocyte
levels as well as CD4+/CD8+ ratio in peripheral blood of combined treatment group were higher
than those of control group while CD8+ T lymphocyte level was lower than that of control
group, and immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM)
levels in peripheral blood were higher than those of control group (P<0.05). Conclusions:
Xiao Chaihu Tang combined with intravenous chemotherapy can decrease the severity of
advanced breast cancer and optimize the body's immune function.
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