Clinical and laboratorial features of oral candidiasis in HIV-positive patients

• Main Authors: Regiane Nogueira Spalanzani, Karine Mattos, Luiza Inahe Marques, Pedro Fernando Diniz Barros, Pamela Iruama Peres Pereira, Anamaria Mello Miranda Paniago, Rinaldo Poncio Mendes, Marilene Rodrigues Chang
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT)
• Series: Revista da Sociedade Brasileira de Medicina Tropical
• Subjects: Candida spp; HIV; Antifungal susceptibility
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300352&lng=en&tlng=en

Abstract INTRODUCTION We describe the clinical and laboratorial features of oral candidiasis in 66 HIV-positive patients. METHODS: Polymerase chain reaction-based techniques were performed for differentiation of Candida spp. isolated from patients at a public teaching hospital in Midwest Brazil. RESULTS: Oral lesions, mainly pseudomembranous, were significantly related to higher levels of immunosuppression. Of 45 Candida isolates, 66.7% were C. albicans. Most of the isolates were susceptible to the antifungal drugs tested. CONCLUSIONS: Oral lesions were associated with higher immunosuppression levels. Lower susceptibility to antifungals by non-albicans isolates supports the importance of surveillance studies using susceptibility tests to aid in the treatment.