The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms

The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms

We have described three uncommon cases of patients who presented with clinical thrombotic events (stroke, pulmonary embolism and deep venous thrombosis) during the course of a hypercalcemia-induced hypercoagulable state. After thorough investigation, the diagnosis of primary hyperparathyroidism - d...

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Main Authors: Theocharis Koufakis, Vasiliki Antonopoulou, Maria Grammatiki, Spyridon N Karras, Ramzi Ajjan, Pantelis Zebekakis, Kalliopi Kotsa
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-07-01
Series:International Journal of Hematology-Oncology and Stem Cell Research
Subjects:
Calcium
Primary hyperparathyroidism
Thrombosis
Stroke
Pulmonary embolism
Deep venous thrombosis
Online Access:https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/858
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spelling doaj-28d1a8755f384d9598b6315ce59f13a32020-11-25T04:06:50ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072018-07-01123The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential MechanismsTheocharis Koufakis0Vasiliki Antonopoulou1Maria Grammatiki2Spyridon N Karras3Ramzi Ajjan4Pantelis Zebekakis5Kalliopi Kotsa6Division of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, GreeceDivision of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, GreeceDivision of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, GreeceDivision of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, GreeceDivision of Cardiovascular and Diabetes Research, Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds Ringgold Standard Institution, Leeds, UKDivision of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, GreeceDivision of Endocrinology and Metabolism - Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece We have described three uncommon cases of patients who presented with clinical thrombotic events (stroke, pulmonary embolism and deep venous thrombosis) during the course of a hypercalcemia-induced hypercoagulable state. After thorough investigation, the diagnosis of primary hyperparathyroidism - due to a parathyroid adenoma - was established in all cases. The association between hypercalcemia and venous or arterial thrombosis has been previously described; however, relevant data are still insufficient. The existing evidence in the field was reviewed and the interesting underlying pathophysiologic mechanisms were also discussed. Further studies are required to shed more light on the unusual, still intriguing relationship between calcium and thrombosis. https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/858CalciumPrimary hyperparathyroidismThrombosisStrokePulmonary embolismDeep venous thrombosis
collection DOAJ
language English
format Article
sources DOAJ
author Theocharis Koufakis
Vasiliki Antonopoulou
Maria Grammatiki
Spyridon N Karras
Ramzi Ajjan
Pantelis Zebekakis
Kalliopi Kotsa
spellingShingle Theocharis Koufakis
Vasiliki Antonopoulou
Maria Grammatiki
Spyridon N Karras
Ramzi Ajjan
Pantelis Zebekakis
Kalliopi Kotsa
The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms
International Journal of Hematology-Oncology and Stem Cell Research
Calcium
Primary hyperparathyroidism
Thrombosis
Stroke
Pulmonary embolism
Deep venous thrombosis
author_facet Theocharis Koufakis
Vasiliki Antonopoulou
Maria Grammatiki
Spyridon N Karras
Ramzi Ajjan
Pantelis Zebekakis
Kalliopi Kotsa
author_sort Theocharis Koufakis
title The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms
title_short The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms
title_full The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms
title_fullStr The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms
title_full_unstemmed The Relationship between Primary Hyperparathyroidism and Thrombotic Events: Report of Three Cases and a Review of Potential Mechanisms
title_sort relationship between primary hyperparathyroidism and thrombotic events: report of three cases and a review of potential mechanisms
publisher Tehran University of Medical Sciences
series International Journal of Hematology-Oncology and Stem Cell Research
issn 2008-2207
publishDate 2018-07-01
description We have described three uncommon cases of patients who presented with clinical thrombotic events (stroke, pulmonary embolism and deep venous thrombosis) during the course of a hypercalcemia-induced hypercoagulable state. After thorough investigation, the diagnosis of primary hyperparathyroidism - due to a parathyroid adenoma - was established in all cases. The association between hypercalcemia and venous or arterial thrombosis has been previously described; however, relevant data are still insufficient. The existing evidence in the field was reviewed and the interesting underlying pathophysiologic mechanisms were also discussed. Further studies are required to shed more light on the unusual, still intriguing relationship between calcium and thrombosis.
topic Calcium
Primary hyperparathyroidism
Thrombosis
Stroke
Pulmonary embolism
Deep venous thrombosis
url https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/858
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