Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes
Background. Asymmetric dimethylarginine (ADMA) is associated with macrovascular disease and possibly with microangiopathy in type 2 diabetes (T2DM). We tested the hypothesis that ADMA is related to diabetic retinopathy (DR) independently of macrovascular disease. Methods. This cross-sectional study...
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doaj-28ef9db5e1fa49d2a7aa9f6ba1b9b0eb2020-11-24T22:31:54ZengHindawi LimitedCardiology Research and Practice2090-05972011-01-01201110.4061/2011/260191260191Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 DiabetesKatarzyna Krzyzanowska0Friedrich Mittermayer1Gerit H. Schernthaner2Simon Brunner3Johanna M. Brix4Stefan Aschauer5Florian Höllerl6Michael Wolzt7Guntram Schernthaner8Internal Medicine 1, Rudolfstiftung Hospital, 1030 Vienna, AustriaClinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaInternal Medicine 2, Medical University of Vienna, 1090 Vienna, AustriaOphtalmology, Rudolfstiftung Hospital, 1030 Vienna, AustriaInternal Medicine 1, Rudolfstiftung Hospital, 1030 Vienna, AustriaClinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaInternal Medicine 1, Rudolfstiftung Hospital, 1030 Vienna, AustriaClinical Pharmacology, Medical University of Vienna, 1090 Vienna, AustriaInternal Medicine 1, Rudolfstiftung Hospital, 1030 Vienna, AustriaBackground. Asymmetric dimethylarginine (ADMA) is associated with macrovascular disease and possibly with microangiopathy in type 2 diabetes (T2DM). We tested the hypothesis that ADMA is related to diabetic retinopathy (DR) independently of macrovascular disease. Methods. This cross-sectional study included 127 T2DM patients selected to achieve equal distributions of patients with and without macrovascular disease in the groups with and without DR. Results. Patients with DR had increased ADMA, longer diabetes duration, and reduced glomerular filtration rate (GFR). ADMA correlated with GFR (𝜌=−0.35; 𝑃<.001), diabetes duration (𝜌=0.19; 𝑃=.048), and age (𝜌=0.19; 𝑃=.033). Logistic regression analysis revealed an association of ADMA with DR. After adjustment for macrovascular disease, this association remained significant (OR 1.48; 95% CI: 1.02–2.15; 𝑃=.039). Inclusion of GFR and T2DM duration into the model abolished this significant relationship. GFR remained the only independent predictor for DR. A 10 mL/min/1.73 m2 GFR decrease was associated with DR in a multivariate model (OR 1.30; 95% CI: 1.08–1.56; 𝑃=.006). Conclusions. These findings indicate an association between ADMA and DR in T2DM independent of macrovascular disease. This relationship is modified by GFR, the only parameter significantly related to DR in multivariate analysis.http://dx.doi.org/10.4061/2011/260191 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katarzyna Krzyzanowska Friedrich Mittermayer Gerit H. Schernthaner Simon Brunner Johanna M. Brix Stefan Aschauer Florian Höllerl Michael Wolzt Guntram Schernthaner |
spellingShingle |
Katarzyna Krzyzanowska Friedrich Mittermayer Gerit H. Schernthaner Simon Brunner Johanna M. Brix Stefan Aschauer Florian Höllerl Michael Wolzt Guntram Schernthaner Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes Cardiology Research and Practice |
author_facet |
Katarzyna Krzyzanowska Friedrich Mittermayer Gerit H. Schernthaner Simon Brunner Johanna M. Brix Stefan Aschauer Florian Höllerl Michael Wolzt Guntram Schernthaner |
author_sort |
Katarzyna Krzyzanowska |
title |
Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes |
title_short |
Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes |
title_full |
Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes |
title_fullStr |
Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes |
title_full_unstemmed |
Renal Function but Not Asymmetric Dimethylarginine Is Independently Associated with Retinopathy in Type 2 Diabetes |
title_sort |
renal function but not asymmetric dimethylarginine is independently associated with retinopathy in type 2 diabetes |
publisher |
Hindawi Limited |
series |
Cardiology Research and Practice |
issn |
2090-0597 |
publishDate |
2011-01-01 |
description |
Background. Asymmetric dimethylarginine (ADMA) is associated with macrovascular disease and possibly with microangiopathy in type 2 diabetes (T2DM). We tested the hypothesis that ADMA is related to diabetic retinopathy (DR) independently of macrovascular disease. Methods. This cross-sectional study included 127 T2DM patients selected to achieve equal distributions of patients with and without macrovascular disease in the groups with and without DR. Results. Patients with DR had increased ADMA, longer diabetes duration, and reduced glomerular filtration rate (GFR). ADMA correlated with GFR (𝜌=−0.35; 𝑃<.001), diabetes duration (𝜌=0.19; 𝑃=.048), and age (𝜌=0.19; 𝑃=.033). Logistic regression analysis revealed an association of ADMA with DR. After adjustment for macrovascular disease, this association remained significant (OR 1.48; 95% CI: 1.02–2.15; 𝑃=.039). Inclusion of GFR and T2DM duration into the model abolished this significant relationship. GFR remained the only independent predictor for DR. A 10 mL/min/1.73 m2 GFR decrease was associated with DR in a multivariate model (OR 1.30; 95% CI: 1.08–1.56; 𝑃=.006). Conclusions. These findings indicate an association between ADMA and DR in T2DM independent of macrovascular disease. This relationship is modified by GFR, the only parameter significantly related to DR in multivariate analysis. |
url |
http://dx.doi.org/10.4061/2011/260191 |
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