A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.
Bibliographic Details
| Main Authors: |
Tadatoshi Sato,
Shiv Verma,
Christian D. Castro Andrade,
Maureen Omeara,
Nia Campbell,
Jialiang S. Wang,
Murat Cetinbas,
Audrey Lang,
Brandon J. Ausk,
Daniel J. Brooks,
Ruslan I. Sadreyev,
Henry M. Kronenberg,
David Lagares,
Yuhei Uda,
Paola Divieti Pajevic,
Mary L. Bouxsein,
Ted S. Gross,
Marc N. Wein |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2020-07-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-020-17099-3
|
|---|
