A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction

Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.

Bibliographic Details
Main Authors: Tadatoshi Sato, Shiv Verma, Christian D. Castro Andrade, Maureen Omeara, Nia Campbell, Jialiang S. Wang, Murat Cetinbas, Audrey Lang, Brandon J. Ausk, Daniel J. Brooks, Ruslan I. Sadreyev, Henry M. Kronenberg, David Lagares, Yuhei Uda, Paola Divieti Pajevic, Mary L. Bouxsein, Ted S. Gross, Marc N. Wein
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17099-3

Internet

https://doi.org/10.1038/s41467-020-17099-3

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