Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence
The morphological changes that occur in myxomatous mitral valve disease (MMVD) involve various components, ultimately leading to the impairment of mitral valve (MV) function. In this context, intrinsic mitral annular abnormalities are increasingly recognized, such as a mitral annular disjunction (MA...
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doaj-28f1b15e98534ca582e06a9c61336d402021-01-25T00:02:30ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-01-0189910.3390/jcdd8020009Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the CoincidenceNina C. Wunderlich0Siew Yen Ho1Nir Flint2Robert J. Siegel3Cardiovasclar Center Darmstadt, 60431 Darmstadt, GermanyCardiac Morphology Unit, Royal Brompton Hospital, London SW3 6NP, UKSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USASmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAThe morphological changes that occur in myxomatous mitral valve disease (MMVD) involve various components, ultimately leading to the impairment of mitral valve (MV) function. In this context, intrinsic mitral annular abnormalities are increasingly recognized, such as a mitral annular disjunction (MAD), a specific anatomical abnormality whereby there is a distinct separation between the mitral annulus and the left atrial wall and the basal portion of the posterolateral left ventricular myocardium. In recent years, several studies have suggested that MAD contributes to myxomatous degeneration of the mitral leaflets, and there is growing evidence that MAD is associated with ventricular arrhythmias and sudden cardiac death. In this review, the morphological characteristics of MAD and imaging tools for diagnosis will be described, and the clinical and functional aspects of the coincidence of MAD and myxomatous MVP will be discussed.https://www.mdpi.com/2308-3425/8/2/9mitral valveprimary mitral regurgitationmyxomatous mitral valve diseasemitral valve prolapsemitral annular disjunctionMitraClip |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nina C. Wunderlich Siew Yen Ho Nir Flint Robert J. Siegel |
spellingShingle |
Nina C. Wunderlich Siew Yen Ho Nir Flint Robert J. Siegel Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence Journal of Cardiovascular Development and Disease mitral valve primary mitral regurgitation myxomatous mitral valve disease mitral valve prolapse mitral annular disjunction MitraClip |
author_facet |
Nina C. Wunderlich Siew Yen Ho Nir Flint Robert J. Siegel |
author_sort |
Nina C. Wunderlich |
title |
Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence |
title_short |
Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence |
title_full |
Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence |
title_fullStr |
Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence |
title_full_unstemmed |
Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence |
title_sort |
myxomatous mitral valve disease with mitral valve prolapse and mitral annular disjunction: clinical and functional significance of the coincidence |
publisher |
MDPI AG |
series |
Journal of Cardiovascular Development and Disease |
issn |
2308-3425 |
publishDate |
2021-01-01 |
description |
The morphological changes that occur in myxomatous mitral valve disease (MMVD) involve various components, ultimately leading to the impairment of mitral valve (MV) function. In this context, intrinsic mitral annular abnormalities are increasingly recognized, such as a mitral annular disjunction (MAD), a specific anatomical abnormality whereby there is a distinct separation between the mitral annulus and the left atrial wall and the basal portion of the posterolateral left ventricular myocardium. In recent years, several studies have suggested that MAD contributes to myxomatous degeneration of the mitral leaflets, and there is growing evidence that MAD is associated with ventricular arrhythmias and sudden cardiac death. In this review, the morphological characteristics of MAD and imaging tools for diagnosis will be described, and the clinical and functional aspects of the coincidence of MAD and myxomatous MVP will be discussed. |
topic |
mitral valve primary mitral regurgitation myxomatous mitral valve disease mitral valve prolapse mitral annular disjunction MitraClip |
url |
https://www.mdpi.com/2308-3425/8/2/9 |
work_keys_str_mv |
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