Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma
Background Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose We aimed to investigate the factors associated with BHR in adolescents with childhood asthma. Methods Two hundred and fifteen adolescents (≥13 years of ag...
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The Korean Pediatric Society
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doaj-28f7984ecf0b430baeb5e19df84d87352021-05-04T06:14:44ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482021-05-0164522923810.3345/cep.2020.0158520125555404Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthmaYoung Hwan Kim0Yoon Young Jang1Jieun Jeong2Hai Lee Chung3 Department of Pediatrics, School of Medicine, Daegu Catholic University, Daegu, Korea Department of Pediatrics, School of Medicine, Daegu Catholic University, Daegu, Korea Department of Pediatrics, School of Medicine, Daegu Catholic University, Daegu, Korea Department of Pediatrics, School of Medicine, Daegu Catholic University, Daegu, KoreaBackground Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose We aimed to investigate the factors associated with BHR in adolescents with childhood asthma. Methods Two hundred and fifteen adolescents (≥13 years of age; 149 males, 66 females) who were diagnosed with asthma during childhood were enrolled, underwent methacholine challenge tests, and were divided into the BHR group (<25 mg/mL of provocation concentration causing a 20% fall in forced expiratory volume in 1 second [FEV1] [PC20], n=113) or non-BHR group (≥25 mg/mL of PC20, n=102). We examined longitudinal changes in BHR and the risk factors for its persistence in the 108 adolescents for whom baseline data, including methacholine PC20 at age 6 years, were available. Multivariate logistic regression analyses were performed to assess the factors associated with BHR in adolescents. Results Mold sensitization (adjusted odds ratio [aOR], 5.569; P=0.005) and increased blood eosinophil count (aOR, 1.002; P=0.026) were independently associated with BHR in boys but not girls. The odds of BHR decreased by 32% with each 1-year increase in age in boys (aOR, 0.683; P=0.010) but not girls. A reduced FEV1/forced vital capacity ratio (<90%) was independently related with BHR in female patients only (aOR, 7.500; P=0.007). BHR decreased with age throughout childhood. A low methacholine PC20 at age 6 years was independently associated with persistent BHR throughout childhood in male and female patients, whereas early mold sensitization was a risk factor for persistent BHR in male patients only (aOR, 7.718; P=0.028). Conclusion Our study revealed sex-specific differences in the factors associated with BHR in adolescents with childhood asthma. Our findings suggest the risk factors that might affect asthma transition from childhood to adolescence and adulthood.http://www.e-cep.org/upload/pdf/cep-2020-01585.pdfadolescenceasthmabronchial hyperresponsivenessmoldsex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Young Hwan Kim Yoon Young Jang Jieun Jeong Hai Lee Chung |
spellingShingle |
Young Hwan Kim Yoon Young Jang Jieun Jeong Hai Lee Chung Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma Clinical and Experimental Pediatrics adolescence asthma bronchial hyperresponsiveness mold sex |
author_facet |
Young Hwan Kim Yoon Young Jang Jieun Jeong Hai Lee Chung |
author_sort |
Young Hwan Kim |
title |
Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma |
title_short |
Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma |
title_full |
Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma |
title_fullStr |
Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma |
title_full_unstemmed |
Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma |
title_sort |
sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma |
publisher |
The Korean Pediatric Society |
series |
Clinical and Experimental Pediatrics |
issn |
2713-4148 |
publishDate |
2021-05-01 |
description |
Background Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose We aimed to investigate the factors associated with BHR in adolescents with childhood asthma. Methods Two hundred and fifteen adolescents (≥13 years of age; 149 males, 66 females) who were diagnosed with asthma during childhood were enrolled, underwent methacholine challenge tests, and were divided into the BHR group (<25 mg/mL of provocation concentration causing a 20% fall in forced expiratory volume in 1 second [FEV1] [PC20], n=113) or non-BHR group (≥25 mg/mL of PC20, n=102). We examined longitudinal changes in BHR and the risk factors for its persistence in the 108 adolescents for whom baseline data, including methacholine PC20 at age 6 years, were available. Multivariate logistic regression analyses were performed to assess the factors associated with BHR in adolescents. Results Mold sensitization (adjusted odds ratio [aOR], 5.569; P=0.005) and increased blood eosinophil count (aOR, 1.002; P=0.026) were independently associated with BHR in boys but not girls. The odds of BHR decreased by 32% with each 1-year increase in age in boys (aOR, 0.683; P=0.010) but not girls. A reduced FEV1/forced vital capacity ratio (<90%) was independently related with BHR in female patients only (aOR, 7.500; P=0.007). BHR decreased with age throughout childhood. A low methacholine PC20 at age 6 years was independently associated with persistent BHR throughout childhood in male and female patients, whereas early mold sensitization was a risk factor for persistent BHR in male patients only (aOR, 7.718; P=0.028). Conclusion Our study revealed sex-specific differences in the factors associated with BHR in adolescents with childhood asthma. Our findings suggest the risk factors that might affect asthma transition from childhood to adolescence and adulthood. |
topic |
adolescence asthma bronchial hyperresponsiveness mold sex |
url |
http://www.e-cep.org/upload/pdf/cep-2020-01585.pdf |
work_keys_str_mv |
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