Pseudomonas aeruginosa Exoprotein-Induced Barrier Disruption Correlates With Elastase Activity and Marks Chronic Rhinosinusitis Severity

Pseudomonas aeruginosa Exoprotein-Induced Barrier Disruption Correlates With Elastase Activity and Marks Chronic Rhinosinusitis Severity

Background:Pseudomonas aeruginosa causes severe chronic respiratory diseases and is associated with recalcitrant chronic rhinosinusitis (CRS). P. aeruginosa exoproteins contain virulence factors and play important roles in the pathogenicity of P. aeruginosa, however their role in CRS pathophysiology...

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Bibliographic Details
Main Authors: Jian Li, Mahnaz Ramezanpour, Stephanie A. Fong, Clare Cooksley, Jae Murphy, Masanobu Suzuki, Alkis J. Psaltis, Peter John Wormald, Sarah Vreugde
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
chronic rhinosinusitis
CT-score
elastase
mucosal barrier
Pseudomonas aeruginosa
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2019.00038/full

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