Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus, may lead to functional tricuspid regurgitation (FTR), where the valve is unable to prevent undesired backflow...
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MDPI AG
2019-05-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/6/2/47 |
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doaj-28fbebd442474b09add3642928cc79472020-11-25T01:36:54ZengMDPI AGBioengineering2306-53542019-05-01624710.3390/bioengineering6020047bioengineering6020047Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical ModelingChung-Hao Lee0Devin W. Laurence1Colton J. Ross2Katherine E. Kramer3Anju R. Babu4Emily L. Johnson5Ming-Chen Hsu6Ankush Aggarwal7Arshid Mir8Harold M. Burkhart9Rheal A. Towner10Ryan Baumwart11Yi Wu12Biomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USABiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USABiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USABiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USABiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USADepartment of Mechanical Engineering, Iowa State University, Ames, IA 50011, USADepartment of Mechanical Engineering, Iowa State University, Ames, IA 50011, USAGlasgow Computational Engineering Centre, School of Engineering, University of Glasgow, Scotland G12 8LT, UKDivision of Pediatric Cardiology, Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USADivision of Cardiothoracic Surgery, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USAAdvance Magnetic Resonance Center, MS 60, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USACenter for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USABiomechanics and Biomaterials Design Laboratory, School of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, OK 73019, USAProper tricuspid valve (TV) function is essential to unidirectional blood flow through the right side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus, may lead to functional tricuspid regurgitation (FTR), where the valve is unable to prevent undesired backflow of blood from the right ventricle into the right atrium during systole. Various treatment options are currently available for FTR; however, research for the tricuspid heart valve, functional tricuspid regurgitation, and the relevant treatment methodologies are limited due to the pervasive expectation among cardiac surgeons and cardiologists that FTR will naturally regress after repair of left-sided heart valve lesions. Recent studies have focused on (i) understanding the function of the TV and the initiation or progression of FTR using both in-vivo and in-vitro methods, (ii) quantifying the biomechanical properties of the tricuspid valve apparatus as well as its surrounding heart tissue, and (iii) performing computational modeling of the TV to provide new insight into its biomechanical and physiological function. This review paper focuses on these advances and summarizes recent research relevant to the TV within the scope of FTR. Moreover, this review also provides future perspectives and extensions critical to enhancing the current understanding of the functioning and remodeling tricuspid valve in both the healthy and pathophysiological states.https://www.mdpi.com/2306-5354/6/2/47the tricuspid valvefunctional tricuspid regurgitationcardiovascular imagingmechanical characterizationin-vitro experimentsconstitutive modelinggeometrical modelingfinite element modelingisogeometric analysis (IGA)biaxial mechanical characterizationfluid-structure interactionsmaterial anisotropysub-valvular components |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chung-Hao Lee Devin W. Laurence Colton J. Ross Katherine E. Kramer Anju R. Babu Emily L. Johnson Ming-Chen Hsu Ankush Aggarwal Arshid Mir Harold M. Burkhart Rheal A. Towner Ryan Baumwart Yi Wu |
| spellingShingle |
Chung-Hao Lee Devin W. Laurence Colton J. Ross Katherine E. Kramer Anju R. Babu Emily L. Johnson Ming-Chen Hsu Ankush Aggarwal Arshid Mir Harold M. Burkhart Rheal A. Towner Ryan Baumwart Yi Wu Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling Bioengineering the tricuspid valve functional tricuspid regurgitation cardiovascular imaging mechanical characterization in-vitro experiments constitutive modeling geometrical modeling finite element modeling isogeometric analysis (IGA) biaxial mechanical characterization fluid-structure interactions material anisotropy sub-valvular components |
| author_facet |
Chung-Hao Lee Devin W. Laurence Colton J. Ross Katherine E. Kramer Anju R. Babu Emily L. Johnson Ming-Chen Hsu Ankush Aggarwal Arshid Mir Harold M. Burkhart Rheal A. Towner Ryan Baumwart Yi Wu |
| author_sort |
Chung-Hao Lee |
| title |
Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling |
| title_short |
Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling |
| title_full |
Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling |
| title_fullStr |
Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling |
| title_full_unstemmed |
Mechanics of the Tricuspid Valve—From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling |
| title_sort |
mechanics of the tricuspid valve—from clinical diagnosis/treatment, in-vivo and in-vitro investigations, to patient-specific biomechanical modeling |
| publisher |
MDPI AG |
| series |
Bioengineering |
| issn |
2306-5354 |
| publishDate |
2019-05-01 |
| description |
Proper tricuspid valve (TV) function is essential to unidirectional blood flow through the right side of the heart. Alterations to the tricuspid valvular components, such as the TV annulus, may lead to functional tricuspid regurgitation (FTR), where the valve is unable to prevent undesired backflow of blood from the right ventricle into the right atrium during systole. Various treatment options are currently available for FTR; however, research for the tricuspid heart valve, functional tricuspid regurgitation, and the relevant treatment methodologies are limited due to the pervasive expectation among cardiac surgeons and cardiologists that FTR will naturally regress after repair of left-sided heart valve lesions. Recent studies have focused on (i) understanding the function of the TV and the initiation or progression of FTR using both in-vivo and in-vitro methods, (ii) quantifying the biomechanical properties of the tricuspid valve apparatus as well as its surrounding heart tissue, and (iii) performing computational modeling of the TV to provide new insight into its biomechanical and physiological function. This review paper focuses on these advances and summarizes recent research relevant to the TV within the scope of FTR. Moreover, this review also provides future perspectives and extensions critical to enhancing the current understanding of the functioning and remodeling tricuspid valve in both the healthy and pathophysiological states. |
| topic |
the tricuspid valve functional tricuspid regurgitation cardiovascular imaging mechanical characterization in-vitro experiments constitutive modeling geometrical modeling finite element modeling isogeometric analysis (IGA) biaxial mechanical characterization fluid-structure interactions material anisotropy sub-valvular components |
| url |
https://www.mdpi.com/2306-5354/6/2/47 |
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