Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance
Therapy resistance is a characteristic of cancer cells that significantly reduces the effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent, which is widely used in the treatment of various types of cancer, resistance of cancer cells to CP chemotherapy has been...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-06-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/11/4002 |
id |
doaj-29010e9856e8467f922faee86d539837 |
---|---|
record_format |
Article |
spelling |
doaj-29010e9856e8467f922faee86d5398372020-11-25T03:31:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-01214002400210.3390/ijms21114002Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin ResistanceMilad Ashrafizadeh0Ali Zarrabi1Kiavash Hushmandi2Mahshad Kalantari3Reza Mohammadinejad4Tahereh Javaheri5Gautam Sethi6Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz 5166616471, IranSabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul 34956, TurkeyDepartment of Food Hygiene and Quality Control, Division of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran 1417414418, IranDepartment of Genetic Science, Tehran Medical Science Branch, Islamic Azad University, Tehran 19168931813, IranPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 1355576169, IranHealth Informatics Lab, Metropolitan College, Boston University, Boston, MA 02215, USADepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeTherapy resistance is a characteristic of cancer cells that significantly reduces the effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent, which is widely used in the treatment of various types of cancer, resistance of cancer cells to CP chemotherapy has been extensively observed. Among various reported mechanism(s), the epithelial–mesenchymal transition (EMT) process can significantly contribute to chemoresistance by converting the motionless epithelial cells into mobile mesenchymal cells and altering cell–cell adhesion as well as the cellular extracellular matrix, leading to invasion of tumor cells. By analyzing the impact of the different molecular pathways such as microRNAs, long non-coding RNAs, nuclear factor-κB (NF-ĸB), phosphoinositide 3-kinase-related protein kinase (PI3K)/Akt, mammalian target rapamycin (mTOR), and Wnt, which play an important role in resistance exhibited to CP therapy, we first give an introduction about the EMT mechanism and its role in drug resistance. We then focus specifically on the molecular pathways involved in drug resistance and the pharmacological strategies that can be used to mitigate this resistance. Overall, we highlight the various targeted signaling pathways that could be considered in future studies to pave the way for the inhibition of EMT-mediated resistance displayed by tumor cells in response to CP exposure.https://www.mdpi.com/1422-0067/21/11/4002cisplatincancer therapychemoresistanceepithelial–mesenchymal transition (EMT)signal transduction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Milad Ashrafizadeh Ali Zarrabi Kiavash Hushmandi Mahshad Kalantari Reza Mohammadinejad Tahereh Javaheri Gautam Sethi |
spellingShingle |
Milad Ashrafizadeh Ali Zarrabi Kiavash Hushmandi Mahshad Kalantari Reza Mohammadinejad Tahereh Javaheri Gautam Sethi Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance International Journal of Molecular Sciences cisplatin cancer therapy chemoresistance epithelial–mesenchymal transition (EMT) signal transduction |
author_facet |
Milad Ashrafizadeh Ali Zarrabi Kiavash Hushmandi Mahshad Kalantari Reza Mohammadinejad Tahereh Javaheri Gautam Sethi |
author_sort |
Milad Ashrafizadeh |
title |
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance |
title_short |
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance |
title_full |
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance |
title_fullStr |
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance |
title_full_unstemmed |
Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin Resistance |
title_sort |
association of the epithelial–mesenchymal transition (emt) with cisplatin resistance |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-06-01 |
description |
Therapy resistance is a characteristic of cancer cells that significantly reduces the effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent, which is widely used in the treatment of various types of cancer, resistance of cancer cells to CP chemotherapy has been extensively observed. Among various reported mechanism(s), the epithelial–mesenchymal transition (EMT) process can significantly contribute to chemoresistance by converting the motionless epithelial cells into mobile mesenchymal cells and altering cell–cell adhesion as well as the cellular extracellular matrix, leading to invasion of tumor cells. By analyzing the impact of the different molecular pathways such as microRNAs, long non-coding RNAs, nuclear factor-κB (NF-ĸB), phosphoinositide 3-kinase-related protein kinase (PI3K)/Akt, mammalian target rapamycin (mTOR), and Wnt, which play an important role in resistance exhibited to CP therapy, we first give an introduction about the EMT mechanism and its role in drug resistance. We then focus specifically on the molecular pathways involved in drug resistance and the pharmacological strategies that can be used to mitigate this resistance. Overall, we highlight the various targeted signaling pathways that could be considered in future studies to pave the way for the inhibition of EMT-mediated resistance displayed by tumor cells in response to CP exposure. |
topic |
cisplatin cancer therapy chemoresistance epithelial–mesenchymal transition (EMT) signal transduction |
url |
https://www.mdpi.com/1422-0067/21/11/4002 |
work_keys_str_mv |
AT miladashrafizadeh associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance AT alizarrabi associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance AT kiavashhushmandi associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance AT mahshadkalantari associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance AT rezamohammadinejad associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance AT taherehjavaheri associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance AT gautamsethi associationoftheepithelialmesenchymaltransitionemtwithcisplatinresistance |
_version_ |
1724574209025245184 |