Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals
Background. Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). Methods. PON1 activity was evaluat...
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doaj-2902804c1aae4faf9b53c30777312d652020-11-25T00:18:39ZengHindawi LimitedDisease Markers0278-02401875-86302014-01-01201410.1155/2014/480201480201Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected IndividualsLuciana Morganti Ferreira Maselli0Joel da Cunha1Eliana Battaggia Gutierrez2Raul Cavalcante Maranhão3Celso Spada4Sérgio Paulo Bydlowski5Laboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo School of Medicine, 05403-000 São Paulo, SP, BrazilLaboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo School of Medicine, 05403-000 São Paulo, SP, BrazilClinics of Parasitic and Infectious Diseases, Hospital and Clinics of the University of São Paulo School of Medicine, 05403-000 São Paulo, SP, BrazilLipid Metabolism Laboratory, Heart Institute, University of São Paulo School of Medicine, 05403-000 São Paulo, SP, BrazilDepartment of Clinical Laboratory, Health Sciences Center, Federal University of Santa Catarina, 88040-900 Florianópolis, SC, BrazilLaboratory of Genetics and Molecular Hematology (LIM31), University of São Paulo School of Medicine, 05403-000 São Paulo, SP, BrazilBackground. Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). Methods. PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-naïve), and 509 were receiving HAART). HIV-1 infected individuals were treated with the following: efavirenz (EFV; n=195) or nevirapine (NVP; n=95) or lopinavir/ritonavir (LOP/r; n=219). Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC : HDL, and LDL : HDL ratios) were determined. Results. PON1 activity (U/L) was lower in the ART-naïve group compared with the other groups. PON1 activity correlated with CD4+ T-cell number of ART-naïve group (r=0,121; P=0,014). The LOP/r group showed a reduction in HDL and an increase in AI (TC : HDL ratio) in comparison with other groups. Conclusion. PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART. PON1 activity correlated with the number of CD4+ T-cells. The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals.http://dx.doi.org/10.1155/2014/480201 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luciana Morganti Ferreira Maselli Joel da Cunha Eliana Battaggia Gutierrez Raul Cavalcante Maranhão Celso Spada Sérgio Paulo Bydlowski |
spellingShingle |
Luciana Morganti Ferreira Maselli Joel da Cunha Eliana Battaggia Gutierrez Raul Cavalcante Maranhão Celso Spada Sérgio Paulo Bydlowski Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals Disease Markers |
author_facet |
Luciana Morganti Ferreira Maselli Joel da Cunha Eliana Battaggia Gutierrez Raul Cavalcante Maranhão Celso Spada Sérgio Paulo Bydlowski |
author_sort |
Luciana Morganti Ferreira Maselli |
title |
Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals |
title_short |
Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals |
title_full |
Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals |
title_fullStr |
Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals |
title_full_unstemmed |
Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals |
title_sort |
human paraoxonase-1 activity is related to the number of cd4+ t-cells and is restored by antiretroviral therapy in hiv-1-infected individuals |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2014-01-01 |
description |
Background. Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). Methods. PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-naïve), and 509 were receiving HAART). HIV-1 infected individuals were treated with the following: efavirenz (EFV; n=195) or nevirapine (NVP; n=95) or lopinavir/ritonavir (LOP/r; n=219). Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC : HDL, and LDL : HDL ratios) were determined. Results. PON1 activity (U/L) was lower in the ART-naïve group compared with the other groups. PON1 activity correlated with CD4+ T-cell number of ART-naïve group (r=0,121; P=0,014). The LOP/r group showed a reduction in HDL and an increase in AI (TC : HDL ratio) in comparison with other groups. Conclusion. PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART. PON1 activity correlated with the number of CD4+ T-cells. The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals. |
url |
http://dx.doi.org/10.1155/2014/480201 |
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