Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study
Abstract Background The incidence of female stroke has increased gradually and has begun occurring at a younger age in recent years. Given that women live longer than men, stroke would cause more negative and longer-term impacts on the rest of the lives of women. There are few related studies on Asi...
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doaj-29083d1ae10846d19a0d1c8ec90b3e332020-11-25T01:43:53ZengBMCBMC Pregnancy and Childbirth1471-23932020-04-0120111010.1186/s12884-020-02898-9Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control studyChun-Chung Huang0Chien-Chu Huang1Shao-Yi Lin2Cherry Yin-Yi Chang3Wu-Chou Lin4Chi-Hsiang Chung5Fu-Huang Lin6Chang-Huei Tsao7Chun-Min Lo8Wu-Chien Chien9Department of Biomedical Engineering, National Yang-Ming UniversityGraduate Institution of Biomedical Sciences, China Medical UniversityDepartment of Mechanical and Computer-Aided Engineering, National Formosa UniversityDepartment of Obstetrics and Gynecology, China Medical University HospitalDepartment of Obstetrics and Gynecology, China Medical University HospitalSchool of Public Health, National Defense Medical CenterSchool of Public Health, National Defense Medical CenterDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical CenterDepartment of Biomedical Engineering, National Yang-Ming UniversityDepartment of Medical Research, Tri-Service General Hospital, National Defense Medical CenterAbstract Background The incidence of female stroke has increased gradually and has begun occurring at a younger age in recent years. Given that women live longer than men, stroke would cause more negative and longer-term impacts on the rest of the lives of women. There are few related studies on Asian women. We aimed to evaluate stroke risk in Asian women following hypertensive pregnancy disorders. Methods Using the Taiwan National Health Insurance database, we designed a retrospective study that included pregnant women between 2000 and 2013. We selected an age-matched control group of women without hypertensive pregnancy disorders at a 1:3 ratio. The endpoint was any episode of stroke; otherwise, the patients were tracked until December 31, 2013. After the index date until the end of 2013, Cox proportional hazards analysis was used to compare the risk of incident stroke. The risk factors for stroke were determined using Cox proportional regression to calculate the hazard ratio (HR) compared with the control group. Results During the follow-up period, the Kaplan-Meier analysis indicated that patients with hypertensive pregnancy disorders had a significantly higher risk of developing stroke than did patients without hypertensive pregnancy disorders (log-rank test P < 0.001). Multivariate Cox regression analysis demonstrated that the case group had a 2.134-fold increased risk of stroke (HR = 2.134; 95% CI = 1.817–2.505; P < 0.001). Conclusion Our study provided evidence of an increased risk of stroke in patients with hypertensive pregnancy disorders. Compared with those without such disorders, the patients who had experienced the disorders had a 2.134-fold (P < 0.001) higher risk of developing stroke in the future.http://link.springer.com/article/10.1186/s12884-020-02898-9Gestational hypertensionPre-eclampsiaEclampsiaCerebrovascular diseaseCVAStroke |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chun-Chung Huang Chien-Chu Huang Shao-Yi Lin Cherry Yin-Yi Chang Wu-Chou Lin Chi-Hsiang Chung Fu-Huang Lin Chang-Huei Tsao Chun-Min Lo Wu-Chien Chien |
spellingShingle |
Chun-Chung Huang Chien-Chu Huang Shao-Yi Lin Cherry Yin-Yi Chang Wu-Chou Lin Chi-Hsiang Chung Fu-Huang Lin Chang-Huei Tsao Chun-Min Lo Wu-Chien Chien Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study BMC Pregnancy and Childbirth Gestational hypertension Pre-eclampsia Eclampsia Cerebrovascular disease CVA Stroke |
author_facet |
Chun-Chung Huang Chien-Chu Huang Shao-Yi Lin Cherry Yin-Yi Chang Wu-Chou Lin Chi-Hsiang Chung Fu-Huang Lin Chang-Huei Tsao Chun-Min Lo Wu-Chien Chien |
author_sort |
Chun-Chung Huang |
title |
Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study |
title_short |
Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study |
title_full |
Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study |
title_fullStr |
Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study |
title_full_unstemmed |
Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study |
title_sort |
association between hypertensive pregnancy disorders and future risk of stroke in taiwan: a nationwide population-based retrospective case-control study |
publisher |
BMC |
series |
BMC Pregnancy and Childbirth |
issn |
1471-2393 |
publishDate |
2020-04-01 |
description |
Abstract Background The incidence of female stroke has increased gradually and has begun occurring at a younger age in recent years. Given that women live longer than men, stroke would cause more negative and longer-term impacts on the rest of the lives of women. There are few related studies on Asian women. We aimed to evaluate stroke risk in Asian women following hypertensive pregnancy disorders. Methods Using the Taiwan National Health Insurance database, we designed a retrospective study that included pregnant women between 2000 and 2013. We selected an age-matched control group of women without hypertensive pregnancy disorders at a 1:3 ratio. The endpoint was any episode of stroke; otherwise, the patients were tracked until December 31, 2013. After the index date until the end of 2013, Cox proportional hazards analysis was used to compare the risk of incident stroke. The risk factors for stroke were determined using Cox proportional regression to calculate the hazard ratio (HR) compared with the control group. Results During the follow-up period, the Kaplan-Meier analysis indicated that patients with hypertensive pregnancy disorders had a significantly higher risk of developing stroke than did patients without hypertensive pregnancy disorders (log-rank test P < 0.001). Multivariate Cox regression analysis demonstrated that the case group had a 2.134-fold increased risk of stroke (HR = 2.134; 95% CI = 1.817–2.505; P < 0.001). Conclusion Our study provided evidence of an increased risk of stroke in patients with hypertensive pregnancy disorders. Compared with those without such disorders, the patients who had experienced the disorders had a 2.134-fold (P < 0.001) higher risk of developing stroke in the future. |
topic |
Gestational hypertension Pre-eclampsia Eclampsia Cerebrovascular disease CVA Stroke |
url |
http://link.springer.com/article/10.1186/s12884-020-02898-9 |
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