Heterogeneity of Hepatic Stellate Cells in Fibrogenesis of the Liver: Insights from Single-Cell Transcriptomic Analysis in Liver Injury

Heterogeneity of Hepatic Stellate Cells in Fibrogenesis of the Liver: Insights from Single-Cell Transcriptomic Analysis in Liver Injury

Background & Aims: Liver fibrosis is a pathological healing process resulting from hepatic stellate cell (HSC) activation and the generation of myofibroblasts from activated HSCs. The precise underlying mechanisms of liver fibrogenesis are still largely vague due to lack of understanding the fun...

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Bibliographic Details
Main Authors: Wenjun Zhang, Simon J. Conway, Ying Liu, Paige Snider, Hanying Chen, Hongyu Gao, Yunlong Liu, Kadir Isidan, Kevin J. Lopez, Gonzalo Campana, Ping Li, Burcin Ekser, Heather Francis, Weinian Shou, Chandrashekhar Kubal
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
single-cell RNA sequencing
hepatic stellate cell sublineage
myofibroblast
liver fibrosis
carbon tetrachloride
Online Access:https://www.mdpi.com/2073-4409/10/8/2129

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