Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10933 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sonja I. Berndt Nicola J. Camp Christine F. Skibola Joseph Vijai Zhaoming Wang Jian Gu Alexandra Nieters Rachel S. Kelly Karin E. Smedby Alain Monnereau Wendy Cozen Angela Cox Sophia S. Wang Qing Lan Lauren R. Teras Moara Machado Meredith Yeager Angela R. Brooks-Wilson Patricia Hartge Mark P. Purdue Brenda M. Birmann Claire M. Vajdic Pierluigi Cocco Yawei Zhang Graham G. Giles Anne Zeleniuch-Jacquotte Charles Lawrence Rebecca Montalvan Laurie Burdett Amy Hutchinson Yuanqing Ye Timothy G. Call Tait D. Shanafelt Anne J. Novak Neil E. Kay Mark Liebow Julie M. Cunningham Cristine Allmer Henrik Hjalgrim Hans-Olov Adami Mads Melbye Bengt Glimelius Ellen T. Chang Martha Glenn Karen Curtin Lisa A. Cannon-Albright W Ryan Diver Brian K. Link George J. Weiner Lucia Conde Paige M. Bracci Jacques Riby Donna K. Arnett Degui Zhi Justin M. Leach Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Núria Sala Delphine Casabonne Nikolaus Becker Paolo Boffetta Paul Brennan Lenka Foretova Marc Maynadie James McKay Anthony Staines Kari G. Chaffee Sara J. Achenbach Celine M. Vachon Lynn R. Goldin Sara S. Strom Jose F. Leis J. Brice Weinberg Neil E. Caporaso Aaron D. Norman Anneclaire J. De Roos Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Rudolph Kaaks Giovanna Masala Elisabete Weiderpass María- Dolores Chirlaque Roel C. H. Vermeulen Ruth C. Travis Melissa C. Southey Roger L. Milne Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Jacqueline Clavel Tongzhang Zheng Theodore R. Holford Danylo J. Villano Ann Maria John J. Spinelli Randy D. Gascoyne Joseph M. Connors Kimberly A. Bertrand Edward Giovannucci Peter Kraft Anne Kricker Jenny Turner Maria Grazia Ennas Giovanni M. Ferri Lucia Miligi Liming Liang Baoshan Ma Jinyan Huang Simon Crouch Ju-Hyun Park Nilanjan Chatterjee Kari E. North John A. Snowden Josh Wright Joseph F. Fraumeni Kenneth Offit Xifeng Wu Silvia de Sanjose James R. Cerhan Stephen J. Chanock Nathaniel Rothman Susan L. Slager |
| spellingShingle |
Sonja I. Berndt Nicola J. Camp Christine F. Skibola Joseph Vijai Zhaoming Wang Jian Gu Alexandra Nieters Rachel S. Kelly Karin E. Smedby Alain Monnereau Wendy Cozen Angela Cox Sophia S. Wang Qing Lan Lauren R. Teras Moara Machado Meredith Yeager Angela R. Brooks-Wilson Patricia Hartge Mark P. Purdue Brenda M. Birmann Claire M. Vajdic Pierluigi Cocco Yawei Zhang Graham G. Giles Anne Zeleniuch-Jacquotte Charles Lawrence Rebecca Montalvan Laurie Burdett Amy Hutchinson Yuanqing Ye Timothy G. Call Tait D. Shanafelt Anne J. Novak Neil E. Kay Mark Liebow Julie M. Cunningham Cristine Allmer Henrik Hjalgrim Hans-Olov Adami Mads Melbye Bengt Glimelius Ellen T. Chang Martha Glenn Karen Curtin Lisa A. Cannon-Albright W Ryan Diver Brian K. Link George J. Weiner Lucia Conde Paige M. Bracci Jacques Riby Donna K. Arnett Degui Zhi Justin M. Leach Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Núria Sala Delphine Casabonne Nikolaus Becker Paolo Boffetta Paul Brennan Lenka Foretova Marc Maynadie James McKay Anthony Staines Kari G. Chaffee Sara J. Achenbach Celine M. Vachon Lynn R. Goldin Sara S. Strom Jose F. Leis J. Brice Weinberg Neil E. Caporaso Aaron D. Norman Anneclaire J. De Roos Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Rudolph Kaaks Giovanna Masala Elisabete Weiderpass María- Dolores Chirlaque Roel C. H. Vermeulen Ruth C. Travis Melissa C. Southey Roger L. Milne Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Jacqueline Clavel Tongzhang Zheng Theodore R. Holford Danylo J. Villano Ann Maria John J. Spinelli Randy D. Gascoyne Joseph M. Connors Kimberly A. Bertrand Edward Giovannucci Peter Kraft Anne Kricker Jenny Turner Maria Grazia Ennas Giovanni M. Ferri Lucia Miligi Liming Liang Baoshan Ma Jinyan Huang Simon Crouch Ju-Hyun Park Nilanjan Chatterjee Kari E. North John A. Snowden Josh Wright Joseph F. Fraumeni Kenneth Offit Xifeng Wu Silvia de Sanjose James R. Cerhan Stephen J. Chanock Nathaniel Rothman Susan L. Slager Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia Nature Communications |
| author_facet |
Sonja I. Berndt Nicola J. Camp Christine F. Skibola Joseph Vijai Zhaoming Wang Jian Gu Alexandra Nieters Rachel S. Kelly Karin E. Smedby Alain Monnereau Wendy Cozen Angela Cox Sophia S. Wang Qing Lan Lauren R. Teras Moara Machado Meredith Yeager Angela R. Brooks-Wilson Patricia Hartge Mark P. Purdue Brenda M. Birmann Claire M. Vajdic Pierluigi Cocco Yawei Zhang Graham G. Giles Anne Zeleniuch-Jacquotte Charles Lawrence Rebecca Montalvan Laurie Burdett Amy Hutchinson Yuanqing Ye Timothy G. Call Tait D. Shanafelt Anne J. Novak Neil E. Kay Mark Liebow Julie M. Cunningham Cristine Allmer Henrik Hjalgrim Hans-Olov Adami Mads Melbye Bengt Glimelius Ellen T. Chang Martha Glenn Karen Curtin Lisa A. Cannon-Albright W Ryan Diver Brian K. Link George J. Weiner Lucia Conde Paige M. Bracci Jacques Riby Donna K. Arnett Degui Zhi Justin M. Leach Elizabeth A. Holly Rebecca D. Jackson Lesley F. Tinker Yolanda Benavente Núria Sala Delphine Casabonne Nikolaus Becker Paolo Boffetta Paul Brennan Lenka Foretova Marc Maynadie James McKay Anthony Staines Kari G. Chaffee Sara J. Achenbach Celine M. Vachon Lynn R. Goldin Sara S. Strom Jose F. Leis J. Brice Weinberg Neil E. Caporaso Aaron D. Norman Anneclaire J. De Roos Lindsay M. Morton Richard K. Severson Elio Riboli Paolo Vineis Rudolph Kaaks Giovanna Masala Elisabete Weiderpass María- Dolores Chirlaque Roel C. H. Vermeulen Ruth C. Travis Melissa C. Southey Roger L. Milne Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Jacqueline Clavel Tongzhang Zheng Theodore R. Holford Danylo J. Villano Ann Maria John J. Spinelli Randy D. Gascoyne Joseph M. Connors Kimberly A. Bertrand Edward Giovannucci Peter Kraft Anne Kricker Jenny Turner Maria Grazia Ennas Giovanni M. Ferri Lucia Miligi Liming Liang Baoshan Ma Jinyan Huang Simon Crouch Ju-Hyun Park Nilanjan Chatterjee Kari E. North John A. Snowden Josh Wright Joseph F. Fraumeni Kenneth Offit Xifeng Wu Silvia de Sanjose James R. Cerhan Stephen J. Chanock Nathaniel Rothman Susan L. Slager |
| author_sort |
Sonja I. Berndt |
| title |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_short |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_full |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_fullStr |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_full_unstemmed |
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| title_sort |
meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease. |
| url |
https://doi.org/10.1038/ncomms10933 |
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doaj-291f7f66c64e40539e0a55a7e9fcad492021-05-11T11:21:20ZengNature Publishing GroupNature Communications2041-17232016-03-01711910.1038/ncomms10933Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemiaSonja I. Berndt0Nicola J. Camp1Christine F. Skibola2Joseph Vijai3Zhaoming Wang4Jian Gu5Alexandra Nieters6Rachel S. Kelly7Karin E. Smedby8Alain Monnereau9Wendy Cozen10Angela Cox11Sophia S. Wang12Qing Lan13Lauren R. Teras14Moara Machado15Meredith Yeager16Angela R. Brooks-Wilson17Patricia Hartge18Mark P. Purdue19Brenda M. Birmann20Claire M. Vajdic21Pierluigi Cocco22Yawei Zhang23Graham G. Giles24Anne Zeleniuch-Jacquotte25Charles Lawrence26Rebecca Montalvan27Laurie Burdett28Amy Hutchinson29Yuanqing Ye30Timothy G. Call31Tait D. Shanafelt32Anne J. Novak33Neil E. Kay34Mark Liebow35Julie M. Cunningham36Cristine Allmer37Henrik Hjalgrim38Hans-Olov Adami39Mads Melbye40Bengt Glimelius41Ellen T. Chang42Martha Glenn43Karen Curtin44Lisa A. Cannon-Albright45W Ryan Diver46Brian K. Link47George J. Weiner48Lucia Conde49Paige M. Bracci50Jacques Riby51Donna K. Arnett52Degui Zhi53Justin M. Leach54Elizabeth A. Holly55Rebecca D. Jackson56Lesley F. Tinker57Yolanda Benavente58Núria Sala59Delphine Casabonne60Nikolaus Becker61Paolo Boffetta62Paul Brennan63Lenka Foretova64Marc Maynadie65James McKay66Anthony Staines67Kari G. Chaffee68Sara J. Achenbach69Celine M. Vachon70Lynn R. Goldin71Sara S. Strom72Jose F. Leis73J. Brice Weinberg74Neil E. Caporaso75Aaron D. Norman76Anneclaire J. De Roos77Lindsay M. Morton78Richard K. Severson79Elio Riboli80Paolo Vineis81Rudolph Kaaks82Giovanna Masala83Elisabete Weiderpass84María- Dolores Chirlaque85Roel C. H. Vermeulen86Ruth C. Travis87Melissa C. Southey88Roger L. Milne89Demetrius Albanes90Jarmo Virtamo91Stephanie Weinstein92Jacqueline Clavel93Tongzhang Zheng94Theodore R. Holford95Danylo J. Villano96Ann Maria97John J. Spinelli98Randy D. Gascoyne99Joseph M. Connors100Kimberly A. Bertrand101Edward Giovannucci102Peter Kraft103Anne Kricker104Jenny Turner105Maria Grazia Ennas106Giovanni M. Ferri107Lucia Miligi108Liming Liang109Baoshan Ma110Jinyan Huang111Simon Crouch112Ju-Hyun Park113Nilanjan Chatterjee114Kari E. North115John A. Snowden116Josh Wright117Joseph F. Fraumeni118Kenneth Offit119Xifeng Wu120Silvia de Sanjose121James R. Cerhan122Stephen J. Chanock123Nathaniel Rothman124Susan L. Slager125Division of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Hematology and Hematologic Malignancies, Department of Internal Medicine, Huntsman Cancer Institute and University of Utah School of MedicineDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at BirminghamDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer InstituteDepartment of Epidemiology, MD Anderson Cancer CenterCenter for Chronic Immunodeficiency, University Medical Center FreiburgDepartment of Epidemiology, Harvard School of Public HealthDepartment of Medicine, Solna, Karolinska Institutet, Karolinska University HospitalEpidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)Department of Preventive Medicine, USC Keck School of Medicine, University of Southern CaliforniaDepartment of Oncology, University of SheffieldDivision of Cancer Etiology, City of Hope Beckman Research InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteEpidemiology Research Program, American Cancer SocietyDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer InstituteGenome Sciences Centre, BC Cancer AgencyDivision of Cancer Epidemiology and Genetics, National Cancer InstituteOntario Health StudyChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolCentre for Big Data Research in Health, University of New South WalesDepartment of Public Health, Clinical and Molecular Medicine, University of CagliariDepartment of Environmental Health Sciences, Yale School of Public HealthCancer Epidemiology Centre, Cancer Council VictoriaDepartment of Population Health, New York University School of MedicineWestatWestatDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer InstituteDepartment of Epidemiology, MD Anderson Cancer CenterDivision of Hematology, Mayo ClinicDepartment of Medicine, Mayo ClinicDepartment of Medicine, Mayo ClinicDivision of Hematology, Mayo ClinicDepartment of Medicine, Mayo ClinicDepartment of Laboratory Medicine and Pathology, Mayo ClinicDepartment of Health Sciences Research, Mayo ClinicDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum InstitutDepartment of Epidemiology, Harvard School of Public HealthDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum InstitutDepartment of Immunology, Genetics and Pathology, Uppsala UniversityCenter for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc.Department of Internal Medicine, Huntsman Cancer InstituteDepartment of Internal Medicine, University of Utah School of MedicineDepartment of Internal Medicine, University of Utah School of MedicineEpidemiology Research Program, American Cancer SocietyDepartment of Internal Medicine, Carver College of Medicine, The University of IowaDepartment of Internal Medicine, Carver College of Medicine, The University of IowaDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at BirminghamDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at BirminghamDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at BirminghamDepartment of Biostatistics, University of Alabama at BirminghamDepartment of Biostatistics, University of Alabama at BirminghamDepartment of Epidemiology and Biostatistics, University of California San FranciscoDivision of Endocrinology, Diabetes and Metabolism, The Ohio State UniversityDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de LlobregatUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de LlobregatUnit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, 08908L’Hospitalet de LlobregatDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)The Tisch Cancer Institute, Icahn School of Medicine at Mount SinaiInternational Agency for Research on Cancer (IARC)Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MUEA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University HospitalInternational Agency for Research on Cancer (IARC)School of Nursing and Human Sciences, Dublin City UniversityDepartment of Health Sciences Research, Mayo ClinicDepartment of Health Sciences Research, Mayo ClinicDepartment of Health Sciences Research, Mayo ClinicDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Epidemiology, MD Anderson Cancer CenterDivision of Hematology/Oncology, Mayo ClinicDepartment of Medicine, Duke University and VA Medical CentersDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Health Sciences Research, Mayo ClinicDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Family Medicine and Public Health Sciences, Wayne State UniversitySchool of Public Health, Imperial College LondonMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College LondonDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO)Department of Medical Epidemiology and Biostatistics, Karolinska InstitutetCIBER de Epidemiología y Salud Pública (CIBERESP)Institute for Risk Assessment Sciences, Utrecht UniversityCancer Epidemiology Unit, University of OxfordDepartment of Pathology, Genetic Epidemiology Laboratory, University of MelbourneCancer Epidemiology Centre, Cancer Council VictoriaDivision of Cancer Epidemiology and Genetics, National Cancer InstituteChronic Disease Prevention Unit, National Institute for Health and WelfareDivision of Cancer Epidemiology and Genetics, National Cancer InstituteEpidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)Department of Environmental Health Sciences, Yale School of Public HealthDepartment of Biostatistics, Yale School of Public HealthDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterCancer Control Research, BC Cancer AgencyCenter for Lymphoid Cancer, BC Cancer AgencyCenter for Lymphoid Cancer, BC Cancer AgencyDepartment of Epidemiology, Harvard School of Public HealthDepartment of Epidemiology, Harvard School of Public HealthDepartment of Epidemiology, Harvard School of Public HealthSydney School of Public Health, The University of SydneyFaculty of Medicine and Health Sciences, Macquarie UniversityDepartment of Biomedical Science, University of CagliariInterdisciplinary Department of Medicine, University of BariEnvironmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO)Department of Epidemiology, Harvard School of Public HealthDepartment of Epidemiology, Harvard School of Public HealthDepartment of Epidemiology, Harvard School of Public HealthDepartment of Health Sciences, University of YorkDepartment of Statistics, Dongguk UniversityDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Epidemiology, University of North Carolina at Chapel HillDepartment of Oncology, University of SheffieldDepartment of Oncology, University of SheffieldDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology, MD Anderson Cancer CenterCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de LlobregatDepartment of Health Sciences Research, Mayo ClinicDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Health Sciences Research, Mayo ClinicChronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.https://doi.org/10.1038/ncomms10933 |