Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01
The first confirmed Rift Valley fever outbreak outside Africa was reported in September 2000, in the Arabian Peninsula. As of February 2001, a total of 884 hospitalized patients were identified in Saudi Arabia, with 124 deaths. In Yemen, 1,087 cases occurred, with 121 deaths. Laboratory diagnosis of...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Centers for Disease Control and Prevention
2002-12-01
|
Series: | Emerging Infectious Diseases |
Subjects: | |
Online Access: | https://wwwnc.cdc.gov/eid/article/8/12/02-0195_article |
id |
doaj-29319924dd554b1796e12fd0c7f96808 |
---|---|
record_format |
Article |
spelling |
doaj-29319924dd554b1796e12fd0c7f968082020-11-25T01:57:52ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592002-12-018121415142010.3201/eid0812.020195Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01Trevor R. ShoemakerCarla BoulianneMartin J. VincentLinda PezzaniteMohammed M. Al-QahtaniYagub Al-MazrouAli S. KhanPierre E. RollinRobert SwanepoelThomas G. KsiazekStuart T. NicholThe first confirmed Rift Valley fever outbreak outside Africa was reported in September 2000, in the Arabian Peninsula. As of February 2001, a total of 884 hospitalized patients were identified in Saudi Arabia, with 124 deaths. In Yemen, 1,087 cases occurred, with 121 deaths. Laboratory diagnosis of Rift Valley fever virus (RVFV) infections included virus genetic detection and characterization of clinical specimens by reverse transcription-polymerase chain reaction, in addition to serologic tests and virus isolation. Genetic analysis of selected regions of virus S, M, and L RNA genome segments indicated little genetic variation among the viruses associated with disease. The Saudi Arabia and Yemen viruses were almost identical to those associated with earlier RVF epidemics in East Africa. Analysis of S, M, and L RNA genome segment sequence differences showed similar phylogenetic relationships among these viruses, indicating that genetic reassortment did not play an important role in the emergence of this virus in the Arabian Peninsula. These results are consistent with the recent introduction of RVFV into the Arabian Peninsula from East Africa.https://wwwnc.cdc.gov/eid/article/8/12/02-0195_articleSaudi ArabiaYemen |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Trevor R. Shoemaker Carla Boulianne Martin J. Vincent Linda Pezzanite Mohammed M. Al-Qahtani Yagub Al-Mazrou Ali S. Khan Pierre E. Rollin Robert Swanepoel Thomas G. Ksiazek Stuart T. Nichol |
spellingShingle |
Trevor R. Shoemaker Carla Boulianne Martin J. Vincent Linda Pezzanite Mohammed M. Al-Qahtani Yagub Al-Mazrou Ali S. Khan Pierre E. Rollin Robert Swanepoel Thomas G. Ksiazek Stuart T. Nichol Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01 Emerging Infectious Diseases Saudi Arabia Yemen |
author_facet |
Trevor R. Shoemaker Carla Boulianne Martin J. Vincent Linda Pezzanite Mohammed M. Al-Qahtani Yagub Al-Mazrou Ali S. Khan Pierre E. Rollin Robert Swanepoel Thomas G. Ksiazek Stuart T. Nichol |
author_sort |
Trevor R. Shoemaker |
title |
Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01 |
title_short |
Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01 |
title_full |
Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01 |
title_fullStr |
Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01 |
title_full_unstemmed |
Genetic Analysis of Viruses Associated with Emergence of Rift Valley Fever in Saudi Arabia and Yemen, 2000-01 |
title_sort |
genetic analysis of viruses associated with emergence of rift valley fever in saudi arabia and yemen, 2000-01 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2002-12-01 |
description |
The first confirmed Rift Valley fever outbreak outside Africa was reported in September 2000, in the Arabian Peninsula. As of February 2001, a total of 884 hospitalized patients were identified in Saudi Arabia, with 124 deaths. In Yemen, 1,087 cases occurred, with 121 deaths. Laboratory diagnosis of Rift Valley fever virus (RVFV) infections included virus genetic detection and characterization of clinical specimens by reverse transcription-polymerase chain reaction, in addition to serologic tests and virus isolation. Genetic analysis of selected regions of virus S, M, and L RNA genome segments indicated little genetic variation among the viruses associated with disease. The Saudi Arabia and Yemen viruses were almost identical to those associated with earlier RVF epidemics in East Africa. Analysis of S, M, and L RNA genome segment sequence differences showed similar phylogenetic relationships among these viruses, indicating that genetic reassortment did not play an important role in the emergence of this virus in the Arabian Peninsula. These results are consistent with the recent introduction of RVFV into the Arabian Peninsula from East Africa. |
topic |
Saudi Arabia Yemen |
url |
https://wwwnc.cdc.gov/eid/article/8/12/02-0195_article |
work_keys_str_mv |
AT trevorrshoemaker geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT carlaboulianne geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT martinjvincent geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT lindapezzanite geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT mohammedmalqahtani geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT yagubalmazrou geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT aliskhan geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT pierreerollin geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT robertswanepoel geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT thomasgksiazek geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 AT stuarttnichol geneticanalysisofvirusesassociatedwithemergenceofriftvalleyfeverinsaudiarabiaandyemen200001 |
_version_ |
1724971955440844800 |