The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer
Purpose. To assess the expression of insulin-like growth factor binding protein (IGFBP) family and its prognostic impact in ovarian cancer (OC) patients. Materials and Methods. The mRNA expression and protein expression of individual IGFBPs in healthy ovarian samples and OC tissues were explored thr...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2020-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2020/7658782 |
id |
doaj-29323f82a7ae429e93075d1dbd811c7a |
---|---|
record_format |
Article |
spelling |
doaj-29323f82a7ae429e93075d1dbd811c7a2020-11-30T09:11:21ZengHindawi LimitedBioMed Research International2314-61332314-61412020-01-01202010.1155/2020/76587827658782The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian CancerRuoyi Zheng0Wenming Chen1Weiting Xia2Jingyu Zheng3Qing Zhou4Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaDepartment of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, ChinaPurpose. To assess the expression of insulin-like growth factor binding protein (IGFBP) family and its prognostic impact in ovarian cancer (OC) patients. Materials and Methods. The mRNA expression and protein expression of individual IGFBPs in healthy ovarian samples and OC tissues were explored through Oncomine, Gene Expression Profiling Interactive Analysis, and Human Protein Atlas database. Additionally, the prognostic values of the six IGFBP members in patients with OC were evaluated by Kaplan-Meier plotter. Results. IGFBP2 and IGFBP4 mRNA expression were remarkably upregulated in patients with OC. To be specific, the mRNA expression of IGFBP2 was upregulated in patients with serous ovarian cancer (SOC), while IGFBP1/3/4/5/6 mRNA levels were downregulated. In addition, the IGFBP4 protein expression was upregulated in SOC, and the IGFBP6 protein expression was upregulated in both of SOC and endometrioid ovarian cancer (EOC) tissues. High IGFBP1 mRNA levels showed favorable overall survival (OS) and progression-free survival (PFS) in all OC. Meanwhile, increased IGFBP5/6 mRNA levels revealed worsen OS and PFS in all OC patients. IGFBP4/6 mRNA levels predicted unfavorable OS and PFS only in SOC patients. Moreover, the aberrant mRNA expression of IGFBP1/2/4/5/6 was correlated with significantly prognosis in patients receiving different chemotherapeutic regimens. Conclusion. This study indicates that the IGFBP family reveals distinct prognosis in patients with OC. IGFBP1/2/4/5/6 are useful prognostic predictors for chemotherapeutic effect in OC patients, and IGFBP2/4 are potential tumor markers for the diagnosis of OC.http://dx.doi.org/10.1155/2020/7658782 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruoyi Zheng Wenming Chen Weiting Xia Jingyu Zheng Qing Zhou |
spellingShingle |
Ruoyi Zheng Wenming Chen Weiting Xia Jingyu Zheng Qing Zhou The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer BioMed Research International |
author_facet |
Ruoyi Zheng Wenming Chen Weiting Xia Jingyu Zheng Qing Zhou |
author_sort |
Ruoyi Zheng |
title |
The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer |
title_short |
The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer |
title_full |
The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer |
title_fullStr |
The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer |
title_full_unstemmed |
The Prognostic Values of the Insulin-Like Growth Factor Binding Protein Family in Ovarian Cancer |
title_sort |
prognostic values of the insulin-like growth factor binding protein family in ovarian cancer |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2020-01-01 |
description |
Purpose. To assess the expression of insulin-like growth factor binding protein (IGFBP) family and its prognostic impact in ovarian cancer (OC) patients. Materials and Methods. The mRNA expression and protein expression of individual IGFBPs in healthy ovarian samples and OC tissues were explored through Oncomine, Gene Expression Profiling Interactive Analysis, and Human Protein Atlas database. Additionally, the prognostic values of the six IGFBP members in patients with OC were evaluated by Kaplan-Meier plotter. Results. IGFBP2 and IGFBP4 mRNA expression were remarkably upregulated in patients with OC. To be specific, the mRNA expression of IGFBP2 was upregulated in patients with serous ovarian cancer (SOC), while IGFBP1/3/4/5/6 mRNA levels were downregulated. In addition, the IGFBP4 protein expression was upregulated in SOC, and the IGFBP6 protein expression was upregulated in both of SOC and endometrioid ovarian cancer (EOC) tissues. High IGFBP1 mRNA levels showed favorable overall survival (OS) and progression-free survival (PFS) in all OC. Meanwhile, increased IGFBP5/6 mRNA levels revealed worsen OS and PFS in all OC patients. IGFBP4/6 mRNA levels predicted unfavorable OS and PFS only in SOC patients. Moreover, the aberrant mRNA expression of IGFBP1/2/4/5/6 was correlated with significantly prognosis in patients receiving different chemotherapeutic regimens. Conclusion. This study indicates that the IGFBP family reveals distinct prognosis in patients with OC. IGFBP1/2/4/5/6 are useful prognostic predictors for chemotherapeutic effect in OC patients, and IGFBP2/4 are potential tumor markers for the diagnosis of OC. |
url |
http://dx.doi.org/10.1155/2020/7658782 |
work_keys_str_mv |
AT ruoyizheng theprognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT wenmingchen theprognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT weitingxia theprognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT jingyuzheng theprognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT qingzhou theprognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT ruoyizheng prognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT wenmingchen prognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT weitingxia prognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT jingyuzheng prognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer AT qingzhou prognosticvaluesoftheinsulinlikegrowthfactorbindingproteinfamilyinovariancancer |
_version_ |
1715028015779414016 |