Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification
In this work, we developed an assay to determine if an arbitrary white powder is a controlled substance, given the plasmonic response of aptamer-gold nanoparticle conjugates (Apt-AuNPs). Toward this end, we designed Apt-AuNPs with specific a response to common controlled substances without cross rea...
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doaj-2933ed697f7747128835c55298cea6d42020-11-25T01:03:30ZengMDPI AGSensors1424-82202017-08-01179193510.3390/s17091935s17091935Cross-Reactive Plasmonic Aptasensors for Controlled Substance IdentificationJoshua N. Yoho0Brian Geier1Claude C. Grigsby2Joshua A. Hagen3Jorge L. Chávez4Nancy Kelley-Loughnane5711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USA711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USA711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USA711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USA711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USA711th Human Performance Wing, Airman Systems Directorate, Air Force Research Laboratory, Wright-Patterson AFB, Dayton, OH 45433, USAIn this work, we developed an assay to determine if an arbitrary white powder is a controlled substance, given the plasmonic response of aptamer-gold nanoparticle conjugates (Apt-AuNPs). Toward this end, we designed Apt-AuNPs with specific a response to common controlled substances without cross reactivity to chemicals typically used as fillers in street formulations. Plasmonic sensor variation was shown to produce unique data fingerprints for each chemical analyzed, supporting the application of multivariate statistical techniques to annotate unknown samples by chemical similarity. Importantly, the assay takes less than fifteen minutes to run, and requires only a few micrograms of the material, making the proposed assay easily deployable in field operations.https://www.mdpi.com/1424-8220/17/9/1935illicit drugsplasmonic sensoraptamergold nanoparticlecross-reactivecolorimetric |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joshua N. Yoho Brian Geier Claude C. Grigsby Joshua A. Hagen Jorge L. Chávez Nancy Kelley-Loughnane |
spellingShingle |
Joshua N. Yoho Brian Geier Claude C. Grigsby Joshua A. Hagen Jorge L. Chávez Nancy Kelley-Loughnane Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification Sensors illicit drugs plasmonic sensor aptamer gold nanoparticle cross-reactive colorimetric |
author_facet |
Joshua N. Yoho Brian Geier Claude C. Grigsby Joshua A. Hagen Jorge L. Chávez Nancy Kelley-Loughnane |
author_sort |
Joshua N. Yoho |
title |
Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification |
title_short |
Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification |
title_full |
Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification |
title_fullStr |
Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification |
title_full_unstemmed |
Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification |
title_sort |
cross-reactive plasmonic aptasensors for controlled substance identification |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2017-08-01 |
description |
In this work, we developed an assay to determine if an arbitrary white powder is a controlled substance, given the plasmonic response of aptamer-gold nanoparticle conjugates (Apt-AuNPs). Toward this end, we designed Apt-AuNPs with specific a response to common controlled substances without cross reactivity to chemicals typically used as fillers in street formulations. Plasmonic sensor variation was shown to produce unique data fingerprints for each chemical analyzed, supporting the application of multivariate statistical techniques to annotate unknown samples by chemical similarity. Importantly, the assay takes less than fifteen minutes to run, and requires only a few micrograms of the material, making the proposed assay easily deployable in field operations. |
topic |
illicit drugs plasmonic sensor aptamer gold nanoparticle cross-reactive colorimetric |
url |
https://www.mdpi.com/1424-8220/17/9/1935 |
work_keys_str_mv |
AT joshuanyoho crossreactiveplasmonicaptasensorsforcontrolledsubstanceidentification AT briangeier crossreactiveplasmonicaptasensorsforcontrolledsubstanceidentification AT claudecgrigsby crossreactiveplasmonicaptasensorsforcontrolledsubstanceidentification AT joshuaahagen crossreactiveplasmonicaptasensorsforcontrolledsubstanceidentification AT jorgelchavez crossreactiveplasmonicaptasensorsforcontrolledsubstanceidentification AT nancykelleyloughnane crossreactiveplasmonicaptasensorsforcontrolledsubstanceidentification |
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1725200979098337280 |