Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture

Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture

Müller glia are a type of retinal glial cell important for maintaining retinal structure and implicated in response to retinal damage. Here the authors identify Brevican, a chondroitin sulfate proteoglycan, as a microRNA-modulated regulator of Müller glia function.

Bibliographic Details
Main Authors: Stefanie G. Wohl, Nikolas L. Jorstad, Edward M. Levine, Thomas A. Reh
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01624-y
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spelling doaj-2934f8e7eaba4145a803c3a1589480702021-05-11T07:33:21ZengNature Publishing GroupNature Communications2041-17232017-11-018111510.1038/s41467-017-01624-yMüller glial microRNAs are required for the maintenance of glial homeostasis and retinal architectureStefanie G. Wohl0Nikolas L. Jorstad1Edward M. Levine2Thomas A. Reh3Department of Biological Structure, University of Washington, Health Sciences CenterDepartment of Biological Structure, University of Washington, Health Sciences CenterDepartment of Ophthalmology and Visual Sciences, Vanderbilt UniversityDepartment of Biological Structure, University of Washington, Health Sciences CenterMüller glia are a type of retinal glial cell important for maintaining retinal structure and implicated in response to retinal damage. Here the authors identify Brevican, a chondroitin sulfate proteoglycan, as a microRNA-modulated regulator of Müller glia function.https://doi.org/10.1038/s41467-017-01624-y
collection DOAJ
language English
format Article
sources DOAJ
author Stefanie G. Wohl
Nikolas L. Jorstad
Edward M. Levine
Thomas A. Reh
spellingShingle Stefanie G. Wohl
Nikolas L. Jorstad
Edward M. Levine
Thomas A. Reh
Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
Nature Communications
author_facet Stefanie G. Wohl
Nikolas L. Jorstad
Edward M. Levine
Thomas A. Reh
author_sort Stefanie G. Wohl
title Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
title_short Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
title_full Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
title_fullStr Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
title_full_unstemmed Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture
title_sort müller glial micrornas are required for the maintenance of glial homeostasis and retinal architecture
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Müller glia are a type of retinal glial cell important for maintaining retinal structure and implicated in response to retinal damage. Here the authors identify Brevican, a chondroitin sulfate proteoglycan, as a microRNA-modulated regulator of Müller glia function.
url https://doi.org/10.1038/s41467-017-01624-y
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AT nikolasljorstad mullerglialmicrornasarerequiredforthemaintenanceofglialhomeostasisandretinalarchitecture
AT edwardmlevine mullerglialmicrornasarerequiredforthemaintenanceofglialhomeostasisandretinalarchitecture
AT thomasareh mullerglialmicrornasarerequiredforthemaintenanceofglialhomeostasisandretinalarchitecture
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