Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging
Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., <i>inflammaging</i>. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of <i>...
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doaj-29401d10071743c4a97b6b6e7991b1b72021-07-01T00:12:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-01226379637910.3390/ijms22126379Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy AgingElisa Roda0Erica Cecilia Priori1Daniela Ratto2Fabrizio De Luca3Carmine Di Iorio4Paola Angelone5Carlo Alessandro Locatelli6Anthea Desiderio7Lorenzo Goppa8Elena Savino9Maria Grazia Bottone10Paola Rossi11Laboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyLaboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, ItalyDepartment of Earth and Environmental Science, University of Pavia, 27100 Pavia, ItalyDepartment of Earth and Environmental Science, University of Pavia, 27100 Pavia, ItalyDepartment of Earth and Environmental Science, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyDepartment of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, ItalyFrailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., <i>inflammaging</i>. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of <i>H. erinaceus</i>, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathways, were assessed focusing on senescent frail animals. <i>H. erinaceus</i> partially recovered the aged-related decline of locomotor performances. Histopathological analyses paralleled by immunocytochemical evaluation of specific molecules strengthened the neuroprotective role of <i>H. erinaceus</i> able to ameliorate cerebellar alterations, i.e., milder volume reduction, slighter molecular layer thickness decrease and minor percentage of shrunken Purkinje neurons, also diminishing inflammation and oxidative stress in frail mice while increasing a key longevity regulator and a neuroprotective molecule. Thus, our present findings demonstrated the efficacy of a non-pharmacological approach, based on the dietary supplementation using <i>H. erinaceus</i> extract, which represent a promising adjuvant therapy to be associated with conventional geriatric treatments.https://www.mdpi.com/1422-0067/22/12/6379healthy agingfrailtycerebellum<i>inflammaging</i>oxidative stressergothioneine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisa Roda Erica Cecilia Priori Daniela Ratto Fabrizio De Luca Carmine Di Iorio Paola Angelone Carlo Alessandro Locatelli Anthea Desiderio Lorenzo Goppa Elena Savino Maria Grazia Bottone Paola Rossi |
spellingShingle |
Elisa Roda Erica Cecilia Priori Daniela Ratto Fabrizio De Luca Carmine Di Iorio Paola Angelone Carlo Alessandro Locatelli Anthea Desiderio Lorenzo Goppa Elena Savino Maria Grazia Bottone Paola Rossi Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging International Journal of Molecular Sciences healthy aging frailty cerebellum <i>inflammaging</i> oxidative stress ergothioneine |
author_facet |
Elisa Roda Erica Cecilia Priori Daniela Ratto Fabrizio De Luca Carmine Di Iorio Paola Angelone Carlo Alessandro Locatelli Anthea Desiderio Lorenzo Goppa Elena Savino Maria Grazia Bottone Paola Rossi |
author_sort |
Elisa Roda |
title |
Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging |
title_short |
Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging |
title_full |
Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging |
title_fullStr |
Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging |
title_full_unstemmed |
Neuroprotective Metabolites of <i>Hericium erinaceus</i> Promote Neuro-Healthy Aging |
title_sort |
neuroprotective metabolites of <i>hericium erinaceus</i> promote neuro-healthy aging |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-06-01 |
description |
Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, typically linked to chronic systemic inflammation, i.e., <i>inflammaging</i>. In the current study, we investigated the effect of a two-month oral supplementation with standardized extracts of <i>H. erinaceus</i>, containing a known amount of Erinacine A, Hericenone C, Hericenone D, and L-ergothioneine, on locomotor frailty and cerebellum of aged mice. Locomotor performances were monitored comparing healthy aging and frail mice. Cerebellar volume and cytoarchitecture, together with inflammatory and oxidative stress pathways, were assessed focusing on senescent frail animals. <i>H. erinaceus</i> partially recovered the aged-related decline of locomotor performances. Histopathological analyses paralleled by immunocytochemical evaluation of specific molecules strengthened the neuroprotective role of <i>H. erinaceus</i> able to ameliorate cerebellar alterations, i.e., milder volume reduction, slighter molecular layer thickness decrease and minor percentage of shrunken Purkinje neurons, also diminishing inflammation and oxidative stress in frail mice while increasing a key longevity regulator and a neuroprotective molecule. Thus, our present findings demonstrated the efficacy of a non-pharmacological approach, based on the dietary supplementation using <i>H. erinaceus</i> extract, which represent a promising adjuvant therapy to be associated with conventional geriatric treatments. |
topic |
healthy aging frailty cerebellum <i>inflammaging</i> oxidative stress ergothioneine |
url |
https://www.mdpi.com/1422-0067/22/12/6379 |
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