Ribavirin enhances the action of interferon-α against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway.

Ribavirin enhances the action of interferon-α against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway.

<h4>Background/aims</h4>Ribavirin significantly enhances the antiviral response of interferon-α (IFN-α) against Hepatitis C virus (HCV), but the underlying mechanisms remain poorly understood. Recently, p53 has been identified as an important factor involving the suppression of HCV repli...

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Bibliographic Details
Main Authors: Wei-Liang Liu, Hung-Chih Yang, Wen-Cheng Su, Chih-Chiang Wang, Hui-Ling Chen, Hurng-Yi Wang, Wen-Hung Huang, Ding-Shinn Chen, Ming-Yang Lai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22962590/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22962590/pdf/?tool=EBI

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