Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer
Background. No predictive or prognostic biomarker is available for patients with locally advanced rectal cancer (LARC) undergoing perioperative chemoradiotherapy (CRT). Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases EGFR (HER1, ERBB1), HER2 (ERBB2), H...
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doaj-294a91ffb6054bd2a9946d1f1ab2685a2020-11-25T00:22:34ZengHindawi LimitedGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/34815783481578Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal CancerMelanie Kripp0Kirsten Merx1Ralph Markus Wirtz2Timo Gaiser3Sebastian Eidt4Juliana Schwaab5Stefan Post6Frederik Wenz7Andreas Hochhaus8Ralf-Dieter Hofheinz9Philipp Erben10III. Medizinische Klinik, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyIII. Medizinische Klinik, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyStratifyer Molecular Pathology GmbH, 50935 Köln, GermanyPathologisches Institut, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyStratifyer Molecular Pathology GmbH, 50935 Köln, GermanyIII. Medizinische Klinik, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyChirurgische Klinik, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyKlinik für Strahlentherapie und Radioonkologie, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyAbteilung Hämatologie/Onkologie, Universitätsklinikum Jena, 07747 Jena, GermanyIII. Medizinische Klinik, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyKlinik für Urologie, Universitätsmedizin Mannheim, 68167 Mannheim, GermanyBackground. No predictive or prognostic biomarker is available for patients with locally advanced rectal cancer (LARC) undergoing perioperative chemoradiotherapy (CRT). Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases EGFR (HER1, ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4) are therapeutic targets in several cancers. The analysis was performed to assess expression levels and study the potential prognostic impact for disease-free and overall survival in patients with LARC. Patients and Methods. ERBB1–4 mRNA expression and tumor proliferation using Ki-67 (MKI67) mRNA were evaluated using RT-quantitative PCR in paraffin-embedded tumor samples from 86 patients (median age: 63) treated with capecitabine or 5-fluorouracil-based CRT within a phase 3 clinical trial. Results. A positive correlation of HER4 and HER2, HER3 and HER2, and HER4 and HER3 with each other was observed. Patients with high mRNA expression of ERBB1 (EGFR, HER1) had significantly increased risk for recurrence and death. Patients with high mRNA expression of MKI67 had reduced risk for relapse. Conclusion. This analysis suggests a prognostic impact of both ERBB1 and MKi67 mRNA expression in LARC patients treated with capecitabine or fluorouracil-based chemoradiotherapy.http://dx.doi.org/10.1155/2016/3481578 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Melanie Kripp Kirsten Merx Ralph Markus Wirtz Timo Gaiser Sebastian Eidt Juliana Schwaab Stefan Post Frederik Wenz Andreas Hochhaus Ralf-Dieter Hofheinz Philipp Erben |
spellingShingle |
Melanie Kripp Kirsten Merx Ralph Markus Wirtz Timo Gaiser Sebastian Eidt Juliana Schwaab Stefan Post Frederik Wenz Andreas Hochhaus Ralf-Dieter Hofheinz Philipp Erben Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer Gastroenterology Research and Practice |
author_facet |
Melanie Kripp Kirsten Merx Ralph Markus Wirtz Timo Gaiser Sebastian Eidt Juliana Schwaab Stefan Post Frederik Wenz Andreas Hochhaus Ralf-Dieter Hofheinz Philipp Erben |
author_sort |
Melanie Kripp |
title |
Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer |
title_short |
Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer |
title_full |
Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer |
title_fullStr |
Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer |
title_full_unstemmed |
Prognostic Impact of mRNA Expression Levels of HER1–4 (ERBB1–4) in Patients with Locally Advanced Rectal Cancer |
title_sort |
prognostic impact of mrna expression levels of her1–4 (erbb1–4) in patients with locally advanced rectal cancer |
publisher |
Hindawi Limited |
series |
Gastroenterology Research and Practice |
issn |
1687-6121 1687-630X |
publishDate |
2016-01-01 |
description |
Background. No predictive or prognostic biomarker is available for patients with locally advanced rectal cancer (LARC) undergoing perioperative chemoradiotherapy (CRT). Members of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases EGFR (HER1, ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4) are therapeutic targets in several cancers. The analysis was performed to assess expression levels and study the potential prognostic impact for disease-free and overall survival in patients with LARC. Patients and Methods. ERBB1–4 mRNA expression and tumor proliferation using Ki-67 (MKI67) mRNA were evaluated using RT-quantitative PCR in paraffin-embedded tumor samples from 86 patients (median age: 63) treated with capecitabine or 5-fluorouracil-based CRT within a phase 3 clinical trial. Results. A positive correlation of HER4 and HER2, HER3 and HER2, and HER4 and HER3 with each other was observed. Patients with high mRNA expression of ERBB1 (EGFR, HER1) had significantly increased risk for recurrence and death. Patients with high mRNA expression of MKI67 had reduced risk for relapse. Conclusion. This analysis suggests a prognostic impact of both ERBB1 and MKi67 mRNA expression in LARC patients treated with capecitabine or fluorouracil-based chemoradiotherapy. |
url |
http://dx.doi.org/10.1155/2016/3481578 |
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