CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8

CUBAN, a Case Study of Selective Binding: Structural Details of the Discrimination between Ubiquitin and NEDD8

The newly identified CUBAN (Cullin binding domain associating with NEDD8) domain recognizes both ubiquitin and the ubiquitin-like NEDD8. Despite the high similarity between the two molecules, CUBAN shows a clear preference for NEDD8, free and conjugated to cullins. We previously characterized the do...

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Bibliographic Details
Main Authors: Elena Santonico, Ridvan Nepravishta, Walter Mandaliti, Luisa Castagnoli, Gianni Cesareni, Maurizio Paci
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
biomolecular NMR
biomolecular recognition
NEDD8
ubiquitin
protein–protein interactions
Online Access:http://www.mdpi.com/1422-0067/20/5/1185

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