Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated. The aim of our study was to investigate the relevance of copper transporters (CTR1 and ATP7A/B), organic cation transporters (OCT2) and the mul...

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Bibliographic Details
Main Authors: Sarah Spreckelmeyer, Margot van der Zee, Benoît Bertrand, Ewen Bodio, Stefan Stürup, Angela Casini
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00377/full