A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated a...
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doaj-2953727471a543f4a61fbd9f19ab7eea2020-11-25T00:42:43ZengMDPI AGNanomaterials2079-49912019-06-019686010.3390/nano9060860nano9060860A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In VitroJi Chen0Guotao Li1Qihong Liu2Yan Liang3Miaochang Liu4Huayue Wu5Wenxia Gao6College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaAccelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.https://www.mdpi.com/2079-4991/9/6/860prodrugphotocleavablestimuli-responsive releasemethotrexatechemotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ji Chen Guotao Li Qihong Liu Yan Liang Miaochang Liu Huayue Wu Wenxia Gao |
spellingShingle |
Ji Chen Guotao Li Qihong Liu Yan Liang Miaochang Liu Huayue Wu Wenxia Gao A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro Nanomaterials prodrug photocleavable stimuli-responsive release methotrexate chemotherapy |
author_facet |
Ji Chen Guotao Li Qihong Liu Yan Liang Miaochang Liu Huayue Wu Wenxia Gao |
author_sort |
Ji Chen |
title |
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro |
title_short |
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro |
title_full |
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro |
title_fullStr |
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro |
title_full_unstemmed |
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro |
title_sort |
photocleavable amphiphilic prodrug self-assembled nanoparticles with effective anticancer activity in vitro |
publisher |
MDPI AG |
series |
Nanomaterials |
issn |
2079-4991 |
publishDate |
2019-06-01 |
description |
Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior. |
topic |
prodrug photocleavable stimuli-responsive release methotrexate chemotherapy |
url |
https://www.mdpi.com/2079-4991/9/6/860 |
work_keys_str_mv |
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