A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated a...

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Bibliographic Details
Main Authors: Ji Chen, Guotao Li, Qihong Liu, Yan Liang, Miaochang Liu, Huayue Wu, Wenxia Gao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Nanomaterials
Subjects:
prodrug
photocleavable
stimuli-responsive release
methotrexate
chemotherapy
Online Access:https://www.mdpi.com/2079-4991/9/6/860
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spelling doaj-2953727471a543f4a61fbd9f19ab7eea2020-11-25T00:42:43ZengMDPI AGNanomaterials2079-49912019-06-019686010.3390/nano9060860nano9060860A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In VitroJi Chen0Guotao Li1Qihong Liu2Yan Liang3Miaochang Liu4Huayue Wu5Wenxia Gao6College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaCollege of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, ChinaAccelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.https://www.mdpi.com/2079-4991/9/6/860prodrugphotocleavablestimuli-responsive releasemethotrexatechemotherapy
collection DOAJ
language English
format Article
sources DOAJ
author Ji Chen
Guotao Li
Qihong Liu
Yan Liang
Miaochang Liu
Huayue Wu
Wenxia Gao
spellingShingle Ji Chen
Guotao Li
Qihong Liu
Yan Liang
Miaochang Liu
Huayue Wu
Wenxia Gao
A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
Nanomaterials
prodrug
photocleavable
stimuli-responsive release
methotrexate
chemotherapy
author_facet Ji Chen
Guotao Li
Qihong Liu
Yan Liang
Miaochang Liu
Huayue Wu
Wenxia Gao
author_sort Ji Chen
title A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_short A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_full A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_fullStr A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_full_unstemmed A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro
title_sort photocleavable amphiphilic prodrug self-assembled nanoparticles with effective anticancer activity in vitro
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2019-06-01
description Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated and self-assembled into nanoparticles for chemotherapy. The nanoparticles exhibited good intracellular uptake and excellent photolysis release of MTX, which resulted in efficient anticancer activity in vitro with laser irradiation. This research provides a way to fabricate photocleavable prodrug nanoparticles with stimuli-triggered drug release behavior.
topic prodrug
photocleavable
stimuli-responsive release
methotrexate
chemotherapy
url https://www.mdpi.com/2079-4991/9/6/860
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