A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

A Photocleavable Amphiphilic Prodrug Self-Assembled Nanoparticles with Effective Anticancer Activity In Vitro

Accelerating degradation of prodrug is an effective strategy for improving the pharmacological action. A photocleavable amphiphilic prodrug of methotrexate-coumarin derivative-PEG conjugates (MTX-AMC-PEG) with photo-triggered breakage to release clinical drug under laser irradiation was fabricated a...

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Bibliographic Details
Main Authors: Ji Chen, Guotao Li, Qihong Liu, Yan Liang, Miaochang Liu, Huayue Wu, Wenxia Gao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Nanomaterials
Subjects:
prodrug
photocleavable
stimuli-responsive release
methotrexate
chemotherapy
Online Access:https://www.mdpi.com/2079-4991/9/6/860

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