SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF 7-HYDROXY-3',4'-DIMETHOXYFLAVONE

• Main Authors: Elfi Susanti VH, Sabirin Matsjeh, Tutik Dwi Wahyuningsih, Mustofa Mustofa, Tri Redjeki
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2012-03-01
• Series: Indonesian Journal of Chemistry
• Subjects: Flavone; chalcone; Claisen-Schmidt condensation; Antioxidant activity
• Online Access: https://jurnal.ugm.ac.id/ijc/article/view/21355

Synthesis of flavones and their derivatives has attracted considerable attention due to their significant pharmaceutical effects. 7-hydroxy-3',4'-dimethoxyflavone has been synthesized and its antioxidant activity has been investigated. Flavone was synthesized by oxidative cyclization of chalcone. 2',4'-dihydroxy-3,4-dimethoxychalcone was prepared by Claisen-Schmidt condensation of 2,4-dihydroxyacetophenones with 3,4-dimethoxybenzaldehydes in the presence of aqueous solution of sodium hydroxide and ethanol at room temperature. Oxidative cyclization of 2',4'-dihydroxy-3,4-dimethoxychalcone was done by using I2 catalyst in DMSO to form 7-hydroxy-3',4'-dimethoxyflavone. The synthesized compounds were characterized by means of their UV-Vis, IR, 1H-NMR and 13C-NMR spectral data. The compound was tested for their antioxidant activities by DPPH method.