Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor

Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor

MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency...

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Bibliographic Details
Main Authors: Shaohua Li, Trung Duc Nguyen, Thuy Linh Nguyen, Tuan Anh Nguyen
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15674-2
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spelling doaj-295c935950d84e4cb61ed4f1f95845a02021-05-11T08:41:47ZengNature Publishing GroupNature Communications2041-17232020-04-0111111710.1038/s41467-020-15674-2Mismatched and wobble base pairs govern primary microRNA processing by human MicroprocessorShaohua Li0Trung Duc Nguyen1Thuy Linh Nguyen2Tuan Anh Nguyen3Division of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyMicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency of Microprocessor processing.https://doi.org/10.1038/s41467-020-15674-2
collection DOAJ
language English
format Article
sources DOAJ
author Shaohua Li
Trung Duc Nguyen
Thuy Linh Nguyen
Tuan Anh Nguyen
spellingShingle Shaohua Li
Trung Duc Nguyen
Thuy Linh Nguyen
Tuan Anh Nguyen
Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
Nature Communications
author_facet Shaohua Li
Trung Duc Nguyen
Thuy Linh Nguyen
Tuan Anh Nguyen
author_sort Shaohua Li
title Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_short Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_full Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_fullStr Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_full_unstemmed Mismatched and wobble base pairs govern primary microRNA processing by human Microprocessor
title_sort mismatched and wobble base pairs govern primary microrna processing by human microprocessor
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-04-01
description MicroRNA genes are transcribed to long primary transcripts called primary microRNAs, which are cleaved by Microprocessor. Here the authors employ high-throughput sequencing and Microprocessor assay to show that mismatches and wobble base pairs in primary microRNAs affect the accuracy and efficiency of Microprocessor processing.
url https://doi.org/10.1038/s41467-020-15674-2
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AT thuylinhnguyen mismatchedandwobblebasepairsgovernprimarymicrornaprocessingbyhumanmicroprocessor
AT tuananhnguyen mismatchedandwobblebasepairsgovernprimarymicrornaprocessingbyhumanmicroprocessor
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