Memantine, Simvastatin, and Epicatechin Inhibit 7-Ketocholesterol-induced Apoptosis in Retinal Pigment Epithelial Cells But Not Neurosensory Retinal Cells In Vitro

Memantine, Simvastatin, and Epicatechin Inhibit 7-Ketocholesterol-induced Apoptosis in Retinal Pigment Epithelial Cells But Not Neurosensory Retinal Cells In Vitro

Purpose: 7-ketocholesterol (7kCh), a natural byproduct of oxidation in lipoprotein deposits is implicated in the pathogenesis of diabetic retinopathy and age-related macular degeneration (AMD). This study was performed to investigate whether several clinical drugs can inhibit 7kCh-induced caspase ac...

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Bibliographic Details
Main Authors: Aneesh Neekhra, Julia Tran, Parsa R. Esfahani, Kevin Schneider, Khoa Pham, Ashish Sharma, Marilyn Chwa, Saurabh Luthra, Ana L. Gramajo, Saffar Mansoor, Baruch D. Kuppermann, M. Cristina Kenney
Format: Article
Language:English
Published: Knowledge E 2020-10-01
Series:Journal of Ophthalmic & Vision Research
Subjects:
epicatechin
7-ketocholesterol
memantine
Online Access:https://doi.org/10.18502/jovr.v15i4.7781

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