α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine

As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (P...

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Main Authors:	Sa Liu, Chunting Zhong, Weiwei Wang, Yongguang Jia, Lin Wang, Li Ren
Format:	Article
Language:	English
Published:	MDPI AG 2018-02-01
Series:	Polymers
Subjects:	polyrotaxane silver sulfadiazine mechanism antibacterial
Online Access:	http://www.mdpi.com/2073-4360/10/2/190

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spelling	doaj-2960d3c42d004cbcb8a6720183e23df52020-11-24T22:20:50ZengMDPI AGPolymers2073-43602018-02-0110219010.3390/polym10020190polym10020190α-Cyclodextrins Polyrotaxane Loading Silver SulfadiazineSa Liu0Chunting Zhong1Weiwei Wang2Yongguang Jia3Lin Wang4Li Ren5School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaAs a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).http://www.mdpi.com/2073-4360/10/2/190polyrotaxanesilver sulfadiazinemechanismantibacterial
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sa Liu Chunting Zhong Weiwei Wang Yongguang Jia Lin Wang Li Ren
spellingShingle	Sa Liu Chunting Zhong Weiwei Wang Yongguang Jia Lin Wang Li Ren α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine Polymers polyrotaxane silver sulfadiazine mechanism antibacterial
author_facet	Sa Liu Chunting Zhong Weiwei Wang Yongguang Jia Lin Wang Li Ren
author_sort	Sa Liu
title	α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
title_short	α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
title_full	α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
title_fullStr	α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
title_full_unstemmed	α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
title_sort	α-cyclodextrins polyrotaxane loading silver sulfadiazine
publisher	MDPI AG
series	Polymers
issn	2073-4360
publishDate	2018-02-01
description	As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).
topic	polyrotaxane silver sulfadiazine mechanism antibacterial
url	http://www.mdpi.com/2073-4360/10/2/190
work_keys_str_mv	AT saliu acyclodextrinspolyrotaxaneloadingsilversulfadiazine AT chuntingzhong acyclodextrinspolyrotaxaneloadingsilversulfadiazine AT weiweiwang acyclodextrinspolyrotaxaneloadingsilversulfadiazine AT yongguangjia acyclodextrinspolyrotaxaneloadingsilversulfadiazine AT linwang acyclodextrinspolyrotaxaneloadingsilversulfadiazine AT liren acyclodextrinspolyrotaxaneloadingsilversulfadiazine
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α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine

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