α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (P...
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doaj-2960d3c42d004cbcb8a6720183e23df52020-11-24T22:20:50ZengMDPI AGPolymers2073-43602018-02-0110219010.3390/polym10020190polym10020190α-Cyclodextrins Polyrotaxane Loading Silver SulfadiazineSa Liu0Chunting Zhong1Weiwei Wang2Yongguang Jia3Lin Wang4Li Ren5School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, ChinaAs a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).http://www.mdpi.com/2073-4360/10/2/190polyrotaxanesilver sulfadiazinemechanismantibacterial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sa Liu Chunting Zhong Weiwei Wang Yongguang Jia Lin Wang Li Ren |
spellingShingle |
Sa Liu Chunting Zhong Weiwei Wang Yongguang Jia Lin Wang Li Ren α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine Polymers polyrotaxane silver sulfadiazine mechanism antibacterial |
author_facet |
Sa Liu Chunting Zhong Weiwei Wang Yongguang Jia Lin Wang Li Ren |
author_sort |
Sa Liu |
title |
α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine |
title_short |
α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine |
title_full |
α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine |
title_fullStr |
α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine |
title_full_unstemmed |
α-Cyclodextrins Polyrotaxane Loading Silver Sulfadiazine |
title_sort |
α-cyclodextrins polyrotaxane loading silver sulfadiazine |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2018-02-01 |
description |
As a drug carrier, polyrotaxane (PR) has been used for targeted delivery and sustained release of drugs, whereas silver sulfadiazine (SD-Ag) is an emerging antibiotic agent. PR was synthesized by the use of α-cyclodextrin (CD) and poly(ethylene glycol) (PEG), and a specific antibacterial material (PR-(SD-Ag)) was then prepared by loading SD-Ag onto PR with different mass ratios. The loading capacity and the encapsulation efficiency were 90% at a mass ratio of 1:1 of PR and SD-Ag. SD-Ag was released stably and slowly within 6 d in vitro, and its cumulative release reached more than 85%. The mechanism of PR loading SD-Ag might be that SD-Ag attached to the edge of α-CD through hydrogen bonding. PR-(SD-Ag) showed a higher light stability than SD-Ag and held excellent antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). |
topic |
polyrotaxane silver sulfadiazine mechanism antibacterial |
url |
http://www.mdpi.com/2073-4360/10/2/190 |
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