Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina
While genetic networks and other intrinsic mechanisms regulate much of retinal development, interactions with the extracellular environment shape these networks and modify their output. The present review has focused on the role of one family of extracellular matrix molecules and their signaling pat...
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doaj-2964a261d008408f9288c4210875e1102020-11-25T01:36:05ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2015-01-0110332933910.4103/2008-322X.170354Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature RetinaShweta VarshneyDale D HunterWilliam J BrunkenWhile genetic networks and other intrinsic mechanisms regulate much of retinal development, interactions with the extracellular environment shape these networks and modify their output. The present review has focused on the role of one family of extracellular matrix molecules and their signaling pathways in retinal development. In addition to their effects on the developing retina, laminins play a role in maintaining Müller cell polarity and compartmentalization, thereby contributing to retinal homeostasis. This article which is intended for the clinical audience, reviews the fundamentals of retinal development, extracellular matrix organization and the role of laminins in retinal development. The role of laminin in cortical development is also briefly discussed.http://www.jovr.org/article.asp?issn=2008-322X;year=2015;volume=10;issue=3;spage=329;epage=339;aulast=VarshneyDystroglycanopathy; Laminin; Müller Cell; Retinal Progenitor Cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shweta Varshney Dale D Hunter William J Brunken |
spellingShingle |
Shweta Varshney Dale D Hunter William J Brunken Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina Journal of Ophthalmic & Vision Research Dystroglycanopathy; Laminin; Müller Cell; Retinal Progenitor Cell |
author_facet |
Shweta Varshney Dale D Hunter William J Brunken |
author_sort |
Shweta Varshney |
title |
Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina |
title_short |
Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina |
title_full |
Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina |
title_fullStr |
Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina |
title_full_unstemmed |
Extracellular Matrix components regulate cellular polarity and tissue structure in the developing and mature Retina |
title_sort |
extracellular matrix components regulate cellular polarity and tissue structure in the developing and mature retina |
publisher |
Knowledge E |
series |
Journal of Ophthalmic & Vision Research |
issn |
2008-322X |
publishDate |
2015-01-01 |
description |
While genetic networks and other intrinsic mechanisms regulate much of retinal development, interactions with the extracellular environment shape these networks and modify their output. The present review has focused on the role of one family of extracellular matrix molecules and their signaling pathways in retinal development. In addition to their effects on the developing retina, laminins play a role in maintaining Müller cell polarity and compartmentalization, thereby contributing to retinal homeostasis. This article which is intended for the clinical audience, reviews the fundamentals of retinal development, extracellular matrix organization and the role of laminins in retinal development. The role of laminin in cortical development is also briefly discussed. |
topic |
Dystroglycanopathy; Laminin; Müller Cell; Retinal Progenitor Cell |
url |
http://www.jovr.org/article.asp?issn=2008-322X;year=2015;volume=10;issue=3;spage=329;epage=339;aulast=Varshney |
work_keys_str_mv |
AT shwetavarshney extracellularmatrixcomponentsregulatecellularpolarityandtissuestructureinthedevelopingandmatureretina AT daledhunter extracellularmatrixcomponentsregulatecellularpolarityandtissuestructureinthedevelopingandmatureretina AT williamjbrunken extracellularmatrixcomponentsregulatecellularpolarityandtissuestructureinthedevelopingandmatureretina |
_version_ |
1725064286400675840 |