Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology
In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefi...
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| Format: | Article |
| Language: | English |
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Sciendo
2012-08-01
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| Series: | ARS Medica Tomitana |
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| Online Access: | https://doi.org/10.2478/v10307-012-0021-y |
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doaj-296cc17e2c8b4048897c80442c5df1ec2021-09-06T19:41:53ZengSciendoARS Medica Tomitana1841-40362012-08-0118310111110.2478/v10307-012-0021-yImmunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathologyVari C.E.0Suciu H.1Ispas Mihaela2Voidăzan S.3Muntean Daniela Lucia4Pharmacology and Clinical Pharmacy DepartmentInstitute of Cardiovascular Diseases and Transplantation Târgu MureşInstitute of Cardiovascular Diseases and Transplantation Târgu MureşEpidemiology DepartmentDrug analysis Department, University of Medicine and Pharmacy Târgu MureşIn a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefit was measured by survival curve and lack of rejection while safety was evaluated by measuring plasma immunosuppressive drugs levels and evaluation of specific adverse events (nephrotoxicity, diabetes, and hypertension). The most frequent side effect was nephrotoxicity (significant reduction in glomerular filtration rate estimated by MDRD formula), but no significant differences were found between the 2 medications.https://doi.org/10.2478/v10307-012-0021-ycyclosporinetacrolimusside effectsheart transplant |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Vari C.E. Suciu H. Ispas Mihaela Voidăzan S. Muntean Daniela Lucia |
| spellingShingle |
Vari C.E. Suciu H. Ispas Mihaela Voidăzan S. Muntean Daniela Lucia Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology ARS Medica Tomitana cyclosporine tacrolimus side effects heart transplant |
| author_facet |
Vari C.E. Suciu H. Ispas Mihaela Voidăzan S. Muntean Daniela Lucia |
| author_sort |
Vari C.E. |
| title |
Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology |
| title_short |
Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology |
| title_full |
Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology |
| title_fullStr |
Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology |
| title_full_unstemmed |
Immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology |
| title_sort |
immunosuppressant medication in cardiac transplant patients - between therapeutic benefit and iatrogenic pathology |
| publisher |
Sciendo |
| series |
ARS Medica Tomitana |
| issn |
1841-4036 |
| publishDate |
2012-08-01 |
| description |
In a retrospective study, the safety profile and efficacy of immunosuppressive medication was evaluated in 35 patients with cardiac transplant in Targu Mures during 1999-2011 (11 treated with cyclosporine, 24 with tacrolimus, both drugs were associated with mycophenolate mofetil). Therapeutic benefit was measured by survival curve and lack of rejection while safety was evaluated by measuring plasma immunosuppressive drugs levels and evaluation of specific adverse events (nephrotoxicity, diabetes, and hypertension). The most frequent side effect was nephrotoxicity (significant reduction in glomerular filtration rate estimated by MDRD formula), but no significant differences were found between the 2 medications. |
| topic |
cyclosporine tacrolimus side effects heart transplant |
| url |
https://doi.org/10.2478/v10307-012-0021-y |
| work_keys_str_mv |
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